Trial reportProbiotics and antimicrobial proteins2026
A Novel Sugar-Free Probiotic Oral Rinse Influences Oral Candida albicans in Children with Down Syndrome Post Complete Oral Rehabilitation: A Pilot Randomized Clinical Trial with 6-Month Follow-Up.
Trial report in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Efficacy of a Microencapsulated Sugar-Free Probiotic Oral Rinse on Gingival Health and Salivary Matrix Metalloproteinases 8 and 9 in Children With Down Syndrome: A Pilot Randomized Clinical Trial.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryTrial
- Gastrointestinal Journey of Human Milk Oligosaccharides: From Breastfeeding Origins to Functional Roles in Adults.Microorganisms · 2025Review
- Probiotics, Prebiotics, Synbiotics, and Postbiotics Against Oral Candida in Children: A Review of Clinical Trials.Nutrients · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Down syndrome (DS), caused by trisomy 21, affects 1 in 600-1000 live births and is associated with distinctive physical features, cognitive impairment, and oral health challenges such as increased susceptibility to dental caries, periodontal disease, and elevated prevalence of oral Candida spp. Barriers to dental care necessitate comprehensive strategies to address the unique oral health needs of children with DS. The aim of the study was to evaluate the effectiveness of a sugar-free probiotic oral rinse versus 0.2% chlorhexidine digluconate in reducing oral Candida albicans (OCA) counts and improving oral health outcomes in children with DS. A double-blind randomized controlled trial (CTRI/2022/10/046847) enrolled 30 children with DS (aged 6-14 years). Baseline evaluations included OCA quantification and oral health assessments (OHI-S and PHP). Following individualized oral rehabilitation, participants were randomized to either a probiotic rinse (Group 1) or chlorhexidine rinse (Group 2) for 2 weeks. OCA and oral health parameters were assessed at baseline (T
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.