ArticleScientific reports2025
Identifying novel risk factors for aneurysmal subarachnoid haemorrhage using machine learning.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Sex disparities in case fatality rate after aneurysmal subarachnoid haemorrhage: a prospective longitudinal population-based cohort study.European stroke journal · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Aneurysmal subarachnoid haemorrhage (aSAH) is a type of stroke with high mortality and morbidity. This study aimed to identify novel aSAH risk factors by combining machine learning (ML) and traditional statistical methods. Using the UK Biobank, we identified aSAH cases via hospital-based ICD codes and analysed 618 baseline variables covering demographics, lifestyle, medical history, and physical measurements. The CatBoost ML algorithm and Shapley Additive Explanations (SHAP) identified the top 25 variables most influential in predicting aSAH. Logistic regression further described these variables while adjusting for established aSAH risk factors. Among 501,847 participants, 893 aSAH cases were identified. ML identified 214 variables with non-zero SHAP values. Logistic regression of the top 25 variables revealed four potential novel aSAH risk factors. Increased aSAH risk was associated with mean sphered cell volume (OR 1.02, 95% CI 1.00-1.03) and tea intake (OR 1.03, 95% CI 1.01-1.05). Decreased aSAH risk was associated with peak expiratory flow (OR 0.80, 95% CI 0.66-0.96), and haematocrit percentage (OR 0.97, 95% CI 0.95-1.00). Future research should validate these findings and explore the potential non-linear relationships and interactions indicated by the ML models.
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Registered trials
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