Evidence map›Paper›PMID 40102249›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025

The influence of hemorrhagic shock on brain perfusion in a swine model of raised intracranial pressure.

Hossam Abdou, Rebecca Treffalls, Grzegorz Jodlowski, Noha Elansary, Thomas Ptak, Patrick F Walker, Jonathan J Morrison

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neuroprotective potential ofVeterinary world · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hossam AbdouR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Rebecca TreffallsDepartment of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA.
Grzegorz JodlowskiDepartment of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0009-0002-2993-6999
Noha ElansaryR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Thomas PtakR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Patrick F WalkerDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Jonathan J MorrisonDepartment of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA. morrison.jonathan@mayo.edu.ORCID http://orcid.org/0000-0001-7462-8456

Funding

Department of Defense #HU0001-19-2-0072, sub-award #4798
6 · The paper itself

Abstract

purposeIn patients with hemorrhagic shock and an intracranial space occupying lesion (SOL), brain perfusion is severely compromised due to raised intracranial pressure (rICP), significantly worsening outcomes. This study aims to develop a swine model of a SOL with rICP and shock and characterize the effect on brain perfusion.

methodsTen male swine were divided into two groups- normal ICP (nICP) and rICP. rICP animals had an intracranial Fogarty balloon catheter inserted, which was infused with saline to simulate a SOL. Animals underwent hemorrhage to systolic blood pressures (SBP) of 60, 40, and 20mmHg. Cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using CT perfusion.

resultsThe CBF/Mean arterial pressure (MAP) and CBV/MAP curves were modeled using non-linear regression, with both groups demonstrating a sigmoid relation. In both the CBF/MAP and CBV/MAP curves, animals with rICP had loss of autoregulation at a higher MAP compared to nICP. The curves were an excellent fit for CBF (nICP R

conclusionsThis study aids in quantifying the compounding insult of raised ICP and hemorrhage with regard to brain perfusion. Raised ICP results in autoregulatory failure at a higher MAP compared to animals with nICP. These results can help inform future studies that should be aimed at evaluating novel interventions for this complex clinical scenario.

Indexed as

BrainCerebrovascular CirculationIntracranial HypertensionShock, HemorrhagicAnimalsCerebral Blood VolumeDisease Models, AnimalIntracranial PressureMaleSwineTomography, X-Ray ComputedCerebral blood flowHemorrhageIntracranial pressurePerfusionSpace occupying lesion

Identifiers

PMID40102249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.