ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025
Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- The Prevalence of Hospitalized Cases of Necrotizing Fasciitis: Anatomical Distribution, Amputations, and In-Hospital Mortality, 2019-2024.Deutsches Arzteblatt international · 2026Observational
- Early recognition of limb necrotizing fasciitis and surgery within six hours is associated with a lower mortality risk and improved patient-reported outcomes.Bone & joint open · 2026Article
- Article
- Multiple skip incision skin-sparing debridement for perianal necrotizing fasciitis: a retrospective study.World journal of emergency surgery : WJES · 2025Article
- Fatal facial necrotizing fasciitis: a case report highlighting diagnostic and therapeutic challenges.Oxford medical case reports · 2025Article
- Necrotizing fasciitis of the head and neck - clinical features, diagnostics, and management strategies.Oncoscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNecrotizing Fasciitis (NF) is a life-threatening infection characterized by rapid tissue destruction and high mortality. The role of timely diagnosis and surgical intervention in improving patient outcomes remains debated. This study investigates the impact of "time to diagnosis" (TTD) and "time to surgical treatment" (TTS) on the outcomes of NF patients, with a specific focus on the first six hours of critical diagnosis.
methodsA retrospective analysis was conducted for patients hospitalized with NF between June 2016 and June 2023. Demographic data, comorbidities, clinical features, treatment, and outcomes were analyzed. The study stratified patients based on TTD (early (≤ 6 h) vs. delayed (> 6 h) and TTS (≤ 6 vs. > 6 h). Outcomes included severity scores, intensive care unit admission, length of stay (LOS), and mortality.
resultsOne hundred and twenty-one patients were diagnosed with NF with a mortality rate of 10%. Early diagnosis (≤ 6 h) was associated with lower mortality (5.7% vs. 13.2%) and shorter LOS (17 vs. 27 days) compared to delayed diagnosis. Early diagnosis was associated with a lower Sequential Organ Failure Assessment (SOFA) score compared to delayed diagnosis (p = 0.02). A combined analysis of TTD and TTS revealed that the group with early diagnosis and early treatment (TTD and TTS were ≤ 6 h) had a 3% mortality rate, and 7% of them had a SOFA score > 9. In contrast, delayed diagnosis (TTD > 6 h) was significantly associated with increased mortality, regardless of the TTS.
conclusionTimely diagnosis within 6 h is crucial for improving outcomes in NF. While early surgical intervention is vital, our findings suggest that the time to diagnosis and subsequent resuscitation efforts may significantly impact survival. This study highlights the importance of optimizing early recognition and diagnosis in the emergency room to reduce delays and improve patient prognosis in NF. Further multicenter studies are needed to validate these findings and refine clinical protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.