Evidence map›Paper›PMID 40102019›Full record

ArticleStroke and vascular neurology2025

Quantitative histopathological analysis of thrombi retrieved by mechanical thrombectomy and their association with stroke aetiology.

Zhiyi Jiang, Juan Huang, Shuntong Hu, Ruping Xiang, Longfeng Ran, Yiwei Chen, Dujie Xie, Panyao Long, Xiaobo Li, Yi Yuan

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke and vascular neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhiyi Jiang *Neurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Juan Huang *Neurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0009-0008-3768-1272
Shuntong HuNeurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0001-9179-7411
Ruping XiangDepartment of Neurology, The Fourth Hospital of Changsha, Changsha, China.
Longfeng RanDepartment of Neurology, The Chengdu First People's Hospital, Chengdu, China.
Yiwei ChenNeurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Dujie XieNeurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Panyao LongNeurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiaobo LiNeurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yi YuanNeurology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China docyuan@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeApproximately 25% of acute large vessel occlusive (LVO) ischaemic strokes are of unknown thrombotic origin, and there is a need to establish the aetiology to guide subsequent preventative measures. The aim of this study was to quantify thrombus composition in patients with LVO and explore associations between thrombus composition and stroke aetiology.

methodsThrombi were extracted from 132 patients with acute ischaemic stroke. Erythrocytes, leucocytes and F+P (fibrin+platelet) proportions were assessed in tissue sections stained with H&E, while CD3

resultsF+P composition was significantly higher (p<0.001) and erythrocyte proportions were significantly lower (p<0.001) in cardioembolic thrombi than in large artery atherosclerosis thrombi. The composition of thrombi from undetermined aetiology strokes resembled that from cardioembolic strokes. CD3

conclusionThere is significant heterogeneity in thrombus composition among different stroke subtypes. The quantitative assessment of thrombus composition may be a useful biomarker of stroke aetiology, and strokes of undetermined aetiology may be more likely to have a cardioembolic origin.

Indexed as

Embolic StrokeIntracranial ThrombosisIschemic StrokeThrombectomyThrombosisThrombotic StrokeAgedAged, 80 and overBlood PlateletsCD3 ComplexErythrocytesExtracellular TrapsFemaleHumansMaleMiddle AgedCD3 ComplexIschemic StrokeThrombectomyThromboembolism

Identifiers

PMID40102019
PMCPMC12772974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.