Evidence map›Paper›PMID 40101936›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2025

Decreases in H2A monoubiquitination in the amygdala constrain fear memory formation.

Yeeun Bae, Harshini Venkat, Natalie Preveza, Meagan Turner, Timothy J Jarome

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yeeun BaeSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
Harshini VenkatSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
Natalie PrevezaSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
Meagan TurnerSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
Timothy J JaromeSchool of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA tjjarome@vt.edu.

Funding

The sex-specific role of degradation-specific protein polyubiquitination in fear memory formationR01MH122414 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JAROME, TIMOTHY JOSEPH · 2021 to 2025
$2.4M
Validating pig models for Alzheimer's diseaseR21AG079292 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI ALLEN, TIMOTHY ALEXANDER, JAROME, TIMOTHY JOSEPH · 2022 to 2022
$447k
Behavioral, molecular and sex-specific mechanisms of indirectly learned fear memoryR21MH131587 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JAROME, TIMOTHY JOSEPH · 2023 to 2024
$433k
IGF2 regulation of microglia and synaptic function during agingR21AG071523 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JAROME, TIMOTHY JOSEPH, ROSENKRANZ, JEREMY E · 2022 to 2023
$433k
Alleviating age-related memory impairment through proteasome stimulationR21AG081851 · NIA · PURDUE UNIVERSITY · PI JAROME, TIMOTHY JOSEPH, TRASK, SYDNEY · 2023 to 2023
$429k
NIA NIH HHS R21 AG071523NIA NIH HHS R21 AG079292NIA NIH HHS R21 AG081851NIMH NIH HHS R01 MH122414NIMH NIH HHS R21 MH131587
6 · The paper itself

Abstract

Evidence suggests a role for monoubiquitination of histone H2B, a regulator of increased gene transcription, in memory formation. However, whether monoubiquitination of histone H2A (H2Aubi), a transcriptional repressor, is involved in memory formation has not been explored. We found global and gene-specific decreases in H2Aubi in the amygdala following fear conditioning. H2Aubi decreased at

Indexed as

AmygdalaFearHistonesMemoryUbiquitinationAnimalsConditioning, ClassicalMaleMiceMice, Inbred C57BLPTEN PhosphohydrolaseUbiquitin-Protein LigasesHistonesPTEN PhosphohydrolaseUbiquitin-Protein Ligases

Identifiers

PMID40101936
PMCPMC11924595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.