Evidence map›Paper›PMID 40101865›Full record

ArticleNeuroImage2025

Resting state brain network segregation is associated with walking speed and working memory in older adults.

Sumire D Sato, Valay A Shah, Tyler Fettrow, Kristina G Hall, Grant D Tays, Erta Cenko, Arkaprava Roy, David J Clark, Daniel P Ferris, Chris J Hass and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Mobility Function and Aperiodic Electrocortical Activity in Younger and Older Adults.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sumire D SatoDepartment of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA. Electronic address: sumiresato@ufl.edu.
Valay A ShahDepartment of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA.
Tyler FettrowDepartment of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA; NASA Langley Research Center, Hampton, VA, USA.
Kristina G HallDepartment of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA.
Grant D TaysDepartment of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA.
Erta CenkoDepartment of Epidemiology, College of Public Health and Health Professions, and College of Medicine, University of Florida, Gainesville, FL, USA.
Arkaprava RoyDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
David J ClarkDepartment of Neurology, University of Florida, Gainesville, FL, USA; Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, FL, USA.
Daniel P FerrisJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Chris J HassDepartment of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA.
Todd M ManiniDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL, USA.
Rachael D SeidlerDepartment of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA; Department of Neurology, University of Florida, Gainesville, FL, USA.

Funding

Multimodal imaging of brain activity to investigate walking and mobility decline in older adultsU01AG061389 · NIA · UNIVERSITY OF FLORIDA · PI CLARK, DAVID J, MANINI, TODD · 2018 to 2023
$5.8M
Advanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M
NIA NIH HHS U01 AG061389NIH HHS S10 OD021726
6 · The paper itself

Abstract

Older adults exhibit larger individual differences in walking ability and cognitive function than young adults. Characterizing intrinsic brain connectivity differences in older adults across a wide walking performance spectrum may provide insight into the mechanisms of functional decline in some older adults and resilience in others. Thus, the objectives of this study were to: (1) determine whether young adults and high- and low-functioning older adults show group differences in brain network segregation, and (2) determine whether network segregation is associated with working memory and walking function in these groups. The analysis included 21 young adults and 81 older adults. Older adults were further categorized according to their physical function using a standardized assessment; 54 older adults had low physical function while 27 were considered high functioning. Structural and functional resting state magnetic resonance images were collected using a Siemens Prisma 3T scanner. Working memory was assessed with the NIH Toolbox list sorting test. Walking speed was assessed with a 400 m walk test at participants' self-selected speed. We found that network segregation in mobility-related networks (sensorimotor, vestibular) was higher in older adults with higher physical function compared to older adults with lower physical function. There were no group differences in laterality effects on network segregation. We found multivariate associations between working memory and walking speed with network segregation scores. The interaction of left sensorimotor network segregation and age groups was associated with higher working memory function. Higher left sensorimotor, left vestibular, right anterior cingulate cortex, and interaction of left anterior cingulate cortex network segregation and age groups were associated with faster walking speed. These results are unique and significant because they demonstrate higher network segregation is largely related to higher physical function and not age alone.

Indexed as

AgingBrainMemory, Short-TermNerve NetWalkingWalking SpeedAdultAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung AdultAgingBehaviorfMRIFunctional connectivityResting stateSegregation

Identifiers

PMID40101865
PMCPMC13263068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.