Evidence map›Paper›PMID 40101287›Full record

ReviewThe American journal of tropical medicine and hygiene2025

Calcified Neurocysticercosis: Understanding Dead (Not Necessarily Inactive) Parasites.

Christina M Coyle, Javier A Bustos, Oscar H Del Brutto, Hector H Garcia, Theodore E Nash, Vedantam Rajshekhar

Abstract readReview
In one paragraph

Review in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christina M CoyleDepartment of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York.
Javier A BustosCenter for Global Health, Universidad Peruana Cayetano Heredia, Lima, Perú.
Oscar H Del BruttoSchool of Medicine and Research Center, Universidad Espíritu Santo - Ecuador, Samborondón, Ecuador.
Hector H GarciaCenter for Global Health, Universidad Peruana Cayetano Heredia, Lima, Perú.
Theodore E NashLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Vedantam RajshekharDepartment of Neurological Sciences, Christian Medical College Ranipet Campus, Vellore, India.

Funding

Training in Parasitic Diseases and Central Nervous System Infections in Peru.D43TW001140 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI GARCIA, HECTOR HUGO, GILMAN, ROBERT H · 1999 to 2025
$5.7M
Using Host Responses to Neurocysticercosis to Develop Novel, Brain-imaging Free Diagnostics: a US-India PartnershipR01NS098891 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CARABIN, HELENE, DREVETS, DOUGLAS ALLEN · 2016 to 2020
$2.6M
FIC NIH HHS D43 TW001140NINDS NIH HHS R01 NS098891
6 · The paper itself

Abstract

Neurocysticercosis (NCC) is the most common helminthic infection of the human central nervous system (CNS), and a major cause of acquired epilepsy in most of the world. Although outcomes of NCC have been improved by advanced diagnostic tests, antiparasitic drugs, and appropriate anti-inflammatory treatment, little attention has been paid to calcified NCC. Calcification is a common outcome in NCC and carries increased risk for seizures and hippocampal atrophy/sclerosis. The pathophysiological mechanisms leading to calcification instead of complete resolution are basically unknown. Understanding the causes and mechanisms of calcification can lead to improved therapies aimed at reducing the likelihood of residual calcification or the underlying pathological mechanisms, after the resolution of parasitic lesions in the human CNS.

Indexed as

CalcinosisNeurocysticercosisAnimalsHumansSeizures

Identifiers

PMID40101287
PMCPMC12139534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.