Evidence map›Paper›PMID 40101143›Full record

ArticleBlood2025

STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL.

Jason Xu, Jonathan H Sussman, Austin Yang, Satoshi Yoshimura, Jianzhong Hu, Changya Chen, Tiffaney Vincent, Shovik Bandyopadhyay, Elizabeth Y Li, Tristan Lim and 27 more

Abstract read
In one paragraph

Article in Blood, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Emerging genomic biomarkers in diagnosis and classification of T-cell acute lymphoblastic leukemia.Hematology. American Society of Hematology. Education Program · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Jason XuGraduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-9061-3593
Jonathan H SussmanGraduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-3057-3550
Austin YangDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0009-0007-1620-3493
Satoshi YoshimuraDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Jianzhong HuDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Changya ChenDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.
Tiffaney VincentDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.
Shovik BandyopadhyayMedical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Elizabeth Y LiDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0001-9501-2263
Tristan LimDepartment of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Omar ElghawyDepartment of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-0786-8035
Adam BarsoukDepartment of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-2333-7530
Damjan KaranfilovskiDepartment of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Shira L WaldDepartment of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Gregory M ChenGraduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
David WuDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0001-6197-7091
Haley NewmanDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-3022-8052
Alexander LiDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.
Yusha SunDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.
Chia-Hui ChenDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0001-5239-1574
Kathrin BerntDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-0691-356X
Brent L WoodDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA.ORCID 0000-0001-7414-3969
Stuart S WinterDivision of Hematology Oncology, Children's Minnesota, Eagan, MN.
Kimberly P DunsmoreDivision of Oncology, University of Virginia Health Sciences Center, Charlottesville, VA.
Elizabeth RaetzDepartment of Pediatrics, New York University Langone Health, New York, NY.
Meenakshi DevidasDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-1099-3478
Stanley PoundsDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-9167-2114
Mignon LohBen Towne Center for Childhood Cancer Research, Seattle Children's Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA.ORCID 0000-0003-4099-4700
Stephen P HungerDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-5492-3957
Mark Y ChiangDivision of Hematology and Oncology, University of Michigan, Ann Arbor, MI.
Caroline DiorioDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.
Danika Di GiacomoDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-5558-7967
Petri PölönenDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0001-6128-9985
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-1871-1850
Jun J YangDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Kai TanDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-9104-5567
David T TeacheyDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0001-7373-8987

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
COG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0M
HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Physician Scientist Training in Clinical OncologyK12CA076931 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STEPHEN Patrick HUNGER, LYNN M. SCHUCHTER · 1997 to 2026
$16.5M
Support for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5M
Data Analysis UnitU2CCA233285 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI HUNGER, STEPHEN PATRICK, TAN, KAI · 2018 to 2023
$13.2M
Organ Specific Project - HeartU54HL165442 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MOFFITT, JEFFREY, PEI, LIMING · 2022 to 2025
$7.6M
Improving risk allocation and developing novel therapies for children with T-ALL and T-LLR01CA193776 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Terzah M Horton, ADAM B OLSHEN · 2015 to 2026
$6.2M
Biomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemiaR01CA264837 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TEACHEY, DAVID T., YANG, JUN J. · 2021 to 2025
$3.0M
Calming the Cytokine Storm: Unraveling the Biology of CRS and ICANSK08CA286762 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Caroline Diorio · 2024 to 2026
$746k
NCI NIH HHS F30 CA268782NCI NIH HHS F30 CA277965NCI NIH HHS K08 CA286762NCI NIH HHS K12 CA076931NCI NIH HHS R01 CA193776NCI NIH HHS R01 CA264837NCI NIH HHS R03 CA256550NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA114766NCI NIH HHS U24 CA196173NCI NIH HHS U2C CA233285NHLBI NIH HHS T32 HL007439NHLBI NIH HHS U54 HL165442NIGMS NIH HHS T32 GM007170
6 · The paper itself

Abstract

abstractWe used single-cell genomics to characterize a patient with T-cell acute lymphoblastic leukemia treated in the Children's Oncology Group AALL0434 trial with poor clinical outcome despite favorable genomic features, identifying a STAT1-mediated interferon-related transcriptional signature and inflammatory microenvironment associated with sensitivity to small-molecule JAK inhibition.

Indexed as

InterferonsJanus Kinase InhibitorsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaSTAT1 Transcription FactorChildDrug Resistance, NeoplasmFemaleHumansMaleInterferonsJanus Kinase InhibitorsSTAT1 protein, humanSTAT1 Transcription Factor

Identifiers

PMID40101143
PMCPMC12163734

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.