Evidence map›Paper›PMID 40100965›Full record

ArticleACS infectious diseases2025

Identification of a New FtsZ Inhibitor by Virtual Screening, Mechanistic Insights, and Structure-Activity Relationship Analyses.

Pietro Sciò, Viola Camilla Scoffone, Anastasia Parisi, Marianna Bufano, Martina Caneva, Gabriele Trespidi, Samuele Irudal, Giulia Barbieri, Lisa Cariani, Beatrice Silvia Orena and 4 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pietro SciòDepartment of Drug Chemistry and Technologies Laboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Sapienza University of Rome, Rome 00185, Italy.
Viola Camilla ScoffoneDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia 27100, Italy.
Anastasia ParisiDepartment of Drug Chemistry and Technologies Laboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Sapienza University of Rome, Rome 00185, Italy.
Marianna BufanoDepartment of Drug Chemistry and Technologies Laboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Sapienza University of Rome, Rome 00185, Italy.
Martina CanevaDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia 27100, Italy.
Gabriele TrespidiDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia 27100, Italy.
Samuele IrudalDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia 27100, Italy.
Giulia BarbieriDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia 27100, Italy.
Lisa CarianiSC Microbiology and Virology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
Beatrice Silvia OrenaSC Microbiology and Virology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
Valeria DaccòPediatric Department, Cystic Fibrosis Pediatric Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
Francesco ImperiDepartment of Science, University of Roma Tre, Rome 00154, Italy.
Silvia BuroniDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia 27100, Italy.
Antonio ColucciaDepartment of Drug Chemistry and Technologies Laboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Sapienza University of Rome, Rome 00185, Italy.ORCID 0000-0002-7940-8206

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a major threat to human health globally. Approximately 5 million deaths were attributed to AMR in 2019, and this figure is predicted to worsen, reaching 10 million deaths by 2050. In the search for new compounds that can tackle AMR, FtsZ inhibitors represent a valuable option. In the present study, a structure-based virtual screening is reported, which led to the identification of derivative

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCytoskeletal ProteinsStaphylococcus aureusAnimalsDrug Evaluation, PreclinicalHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular Docking SimulationMothsStaphylococcal InfectionsStructure-Activity RelationshipAnti-Bacterial AgentsBacterial ProteinsCytoskeletal ProteinsFtsZ protein, Bacteriaantibioticsantimicrobial resistancedrug discoveryFtsZvirtual screening

Identifiers

PMID40100965
PMCPMC11998009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.