ArticleClinical and experimental dental research2025
Comparison of Bone Formation After Early and Late Secondary Alveolar Bone Grafting in Patients With Unilateral and Bilateral Cleft Lip and Palate.
Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesLate-stage secondary alveolar bone grafting (SBG) has a poor prognosis; however, the case selection and timing of orthodontic treatment have not been thoroughly investigated. This study aimed to clarify the prognosis of early-SBG and late-SBG in patients with unilateral or bilateral cleft lip and palate. MATERIALS AND
methodsFifty-six patients underwent early-SBG performed before the eruption of the cleft-adjacent lateral incisors or canines (early-SBG group). Ten patients underwent late-SBG requiring significant tooth movement for gap closure; SBG was performed before phase II treatment for treatment efficiency, and tooth movement began approximately 3 months post-SBG (late-SBG group). Pre-SBG cleft width was measured; bone-bridge formation using the Chelsea scale and cleft gap closure post-SBG were evaluated. Types A and C bone bridges were considered adequate. These items were statistically compared between groups.
resultsCleft width in the early-SBG group was significantly smaller than that in the late-SBG group (p < 0.001). There were no significant differences in the percentage of adequate bone-bridge formation (p = 0.055) and cleft-gap closure (p = 1.000) between groups. However, the ratio of type A bone bridges was significantly higher in the early-SBG group than in the late-SBG group (p = 0.035).
conclusionThese results suggest that, even in late-SBG, early orthodontic tooth movement to the graft bone leads to the formation of an adequate bone bridge, similar to early-SBG. However, the maintenance of cervical grafted bone after late-SBG may be less than that after early-SBG.
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