Evidence map›Paper›PMID 40100636›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Hair cell apoptosis and deafness in

Maryline Beurg, Dakota Elle Konrad, Robert Fettiplace

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. CaProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maryline BeurgDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706.
Dakota Elle KonradDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706.
Robert FettiplaceDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706.ORCID 0000-0003-0754-7239

Funding

INTRACELLULAR CALCIUM IN HAIR CELLSR01DC001362 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT FETTIPLACE · 1992 to 2026
$11.3M
HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC01362NIDCD NIH HHS R01 DC001362
6 · The paper itself

Abstract

Transmembrane channel-like protein 1 (TMC1), a pore-forming component of the mechano-electrical transducer (MET) channel in cochlear outer hair cells, is subject to numerous mutations causing deafness and hair cell death. We studied mice harboring semidominant mutations

Indexed as

ApoptosisDeafnessHair Cells, AuditoryMembrane ProteinsMutationAnimalsEvoked Potentials, Auditory, Brain StemMiceMitochondriaMembrane ProteinsTMC1 protein, mouseapoptosisdeafnesshair cellmitochondriaTMC1

Identifiers

PMID40100636
PMCPMC11962449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.