Evidence map›Paper›PMID 40100622›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

ACOD1-mediated lysosomal membrane permeabilization contributes to

Ziwei Yang, Li Zhang, Samantha Ottavi, Jacob B Geri, Andrew Perkowski, Xiuju Jiang, Daniel Pfau, Ruslana Bryk, Jeffrey Aubé, Matthew Zimmerman and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026
    Review
  4. Review
  5. Article
  6. Role of itaconate in intestinal disease (Review).International journal of molecular medicine · 2026
    Review
  7. Article
  8. Review
  9. Recent insights into HSP70: proteostasis and beyond.Frontiers in molecular biosciences · 2026
    Review
  10. Review
  11. bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ziwei Yang *Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065.
Li Zhang *Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Samantha OttaviDivision of Chemical Biology and Medicinal Chemistry, University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Jacob B GeriDepartment of Pharmacology, Weill Cornell Medicine, New York, NY 10065.
Andrew PerkowskiDivision of Chemical Biology and Medicinal Chemistry, University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Xiuju JiangDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065.
Daniel PfauDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065.
Ruslana BrykDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065.
Jeffrey AubéDivision of Chemical Biology and Medicinal Chemistry, University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0003-1049-5767
Matthew ZimmermanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.ORCID 0000-0001-9470-5009
Carl NathanDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065.ORCID 0000-0002-7744-8896

Funding

Discovery of Phospopantetheinyl Transferse Inhibitors Against Mycobacterium tuberculosisR01AI155510 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AUBE, JEFFREY · 2021 to 2024
$3.1M
Mechanisms of macrophage death co-dependent on M. tuberculosis and IFN-a,b receptorR21AI178133 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI NATHAN, CARL FRANCIS · 2023 to 2024
$466k
Abby and Howard P. Milstein Program in Chemical Biology and Translational Medicine (no number)Cancer Research Institute (CRI) FellowshipHHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) R21AI178133HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) ROIAI155510NIAID NIH HHS R01 AI155510NIAID NIH HHS R21 AI178133
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carboxy-LyasesIntracellular MembranesLysosomesMacrophagesMycobacterium tuberculosisTuberculosisAnimalsCell DeathHSP70 Heat-Shock ProteinsHumansMiceMice, Inbred C57BLPermeabilityCarboxy-LyasesHSP70 Heat-Shock ProteinsACOD1IRG1lysosomesmacrophagestuberculosis

Identifiers

PMID40100622
PMCPMC11962489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.