Xenogeneic Animal Models of Graft-Versus-Host Disease.

Ronald Sluyter, Chloe Sligar, Amal Elhage, Kang Min Chu, Debbie Watson

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ronald SluyterMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia. rsluyter@uow.edu.au.ORCID https://orcid.org/0000-0003-4909-686X

Chloe SligarMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0000-0002-9214-0742

Amal ElhageMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0000-0003-0625-3183

Kang Min ChuMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0009-0009-9861-7706

Debbie WatsonMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0000-0002-6242-3944

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is used to treat malignant and non-malignant blood disorders, but its efficacy is limited by the development of graft-versus-host disease (GVHD). Thus, better understanding and new biomarkers and therapies are required to combat this disease. Xenogeneic animal models of GVHD help to address these gaps and to translate findings from allogeneic animal models of GVHD and other laboratory findings to human allogeneic HSCT recipients. This chapter discusses different humanized mouse models used to study GVHD. Further, this chapter introduces a humanized rat model of GVHD, as well as other xenogeneic models of GVHD in which immune-deficient mice receive blood cells from dogs, cows, or horses. Collectively, this chapter serves as a brief account of xenogeneic animal models of GVHD.

Indexed as

Disease Models, AnimalGraft vs Host DiseaseHematopoietic Stem Cell TransplantationAnimalsCattleDogsHorsesHumansMiceRatsTransplantation, HeterologousTransplantation, HomologousBovineCanineEquineHumanLeukemiaLeukocytesLymphocytesMurineRodentXenogeneic graft-versus-host disease

Identifiers

PMID40100592

DOI10.3390/ani11102962

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.