Evidence map›Paper›PMID 40100573›Full record

ArticleBiological trace element research2025

Two-Dose Crossover Iodine Balance Study: Iodine Requirements for Toddlers in China.

Yan Song, Ying Zhang, Haohao Meng, Jie Liu, Wenwen Gu, Xiru Wang, Zhongna Sang

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Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yan Song *Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Key Laboratory of Environmental Nutrition and Population Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Ying Zhang *Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Key Laboratory of Environmental Nutrition and Population Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Haohao Meng *Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Key Laboratory of Environmental Nutrition and Population Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Jie LiuHedong District Center for Disease Control and Prevention, Tianjin, 300171, China.
Wenwen GuHebei District Center for Disease Control and Prevention, Tianjin, 300143, China.
Xiru WangDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Key Laboratory of Environmental Nutrition and Population Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Zhongna SangDepartment of Nutrition and Food Hygiene, School of Public Health, Tianjin Key Laboratory of Environmental Nutrition and Population Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, Tianjin, 300070, China. sangzhongna@tmu.edu.cn.ORCID http://orcid.org/0000-0002-0234-7214

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a possibility that the iodine requirement for toddlers currently used in China is underestimated. This study aimed to conduct an iodine balance study in Chinese toddlers. We used a two-dose crossover experimental design, relying on the local iodine concentration in drinking water, and adjusting the iodine intake level by adjusting the toddlers' daily consumption of local drinking water. We measured daily iodine intake, excretion, and retention in toddlers and used linear mixed-effects models were used to fit the relationship between total iodine intake and iodine retention. This study involved 26 toddlers aged 2-3 years. Based on the daily total iodine intake and iodine balance values of the toddlers, a mixed effects model was applied to fit the regression curve, and the regression equation was obtained: y = 0.214x - 16.68, from which the EAR and RNI levels of the toddlers were calculated to be approximately 80 µg/day, and 110 µg/day, respectively. In our study, we expected the reference values for daily iodine EAR and RNI levels in toddlers with their current iodine nutrition status to be about 80 µg/day and 110 µg/day, respectively.

Indexed as

IodineNutritional RequirementsChild, PreschoolChinaCross-Over StudiesDrinking WaterFemaleHumansMaleNutritional StatusDrinking WaterIodineEstimated average requirementIodine balance studyRecommended nutrient intakeToddlersUrine iodine

Identifiers

PMID40100573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.