Evidence map›Paper›PMID 40100566›Full record

ArticleBrain imaging and behavior2025

Investigating the neural network correlates of apathy, disinhibition, and executive dysfunction in active-duty United States Special Operations Forces.

Natalie Gilmore, Isabella R McKinney, Chieh-En J Tseng, Douglas N Greve, Chiara Maffei, Brian C Healy, Nicole R Zürcher, Jacob M Hooker, Samantha L Tromly, Daniel P Perl and 4 more

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Natalie GilmoreCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Isabella R McKinneyCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Chieh-En J TsengDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Douglas N GreveDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Chiara MaffeiCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Brian C HealyDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Nicole R ZürcherDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Jacob M HookerDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Samantha L TromlyInstitute of Applied Engineering, University of South Florida, Tampa, FL, 33612, USA.
Daniel P PerlDepartment of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Kristen Dams-O'ConnorDepartment of Rehabilitation and Human Performance, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Christine L Mac DonaldDepartment of Neurological Surgery, University of Washington, Seattle, WA, 98195, USA.
Brian L EdlowCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Yelena G BodienCenter for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, 02114, USA. ybodien@mgh.harvard.edu.

Funding

U.S. Department of Defense H9240520D0001
6 · The paper itself

Abstract

United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 29 male active-duty SOF with mean (SD) 17(4) years of service, we tested whether self-reported symptoms of apathy, disinhibition, and executive dysfunction measured by the Frontal Systems Behavior Scale, were related to functional magnetic resonance imaging and positron emission tomography biomarkers (translocator protein and tau) of the limbic, salience, and executive control networks. Higher disinhibition was associated with lower functional connectivity and higher tau signal within the salience network, though both associations diminished with age. These findings provide the basis for future multimodal studies to elucidate the relationship between neurobehavioral symptoms and neuroimaging biomarkers in the context of repeated blast exposure.

Indexed as

ApathyBrainExecutive FunctionInhibition, PsychologicalMilitary PersonnelAdultBrain MappingHumansMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPositron-Emission Tomographytau ProteinsUnited StatesYoung Adulttau ProteinsBlast injuriesFunctional magnetic resonance imagingMilitary personnelNeurobehavioral symptomsPositron emission tomography

Identifiers

PMID40100566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.