Evidence map›Paper›PMID 40100557›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Frailty and urinary symptoms share pathophysiological mechanisms involved in disease progression in people with multiple sclerosis.

Angelo Di Santo, Leonardo Malimpensa, Marco Canevelli, Alessandra Zampelli, Daniele Belvisi, Giorgio Leodori, Flavio Forte, Antonella Giannantoni, Giuseppe Bruno, Antonella Conte and 1 more

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Frailty, urinary symptoms, comorbidity and multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  2. Letter to the Editor "Frailty and urinary symptoms share pathophysiological mechanisms involved in disease progression in people with multiple sclerosis".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angelo Di Santo *University of Rome "Foro Italic", Via dei Robilant 1, Rome, 00135, Italy.
Leonardo Malimpensa *IRCCS NEUROMED, Via Atinense 18, Pozzilli, 86077, Italy.
Marco CanevelliDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.
Alessandra ZampelliUrology Department, Ospedale Madre Giuseppina Vannini, Via di Acqua Bullicante 4, Rome, 00177, Italy.
Daniele BelvisiIRCCS NEUROMED, Via Atinense 18, Pozzilli, 86077, Italy.
Giorgio LeodoriIRCCS NEUROMED, Via Atinense 18, Pozzilli, 86077, Italy.
Flavio ForteUrology Department, Ospedale Madre Giuseppina Vannini, Via di Acqua Bullicante 4, Rome, 00177, Italy.
Antonella GiannantoniDiagnosis and Treatment of Pelvic Floor Dysfunction Unit, Department of Urology, San Camillo De Lellis Hospital, Viale Kennedy, Rieti, 02100, Italy.
Giuseppe BrunoDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy.
Antonella ConteIRCCS NEUROMED, Via Atinense 18, Pozzilli, 86077, Italy.
Gina FerrazzanoDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, Italy. gina.ferrazzano@uniroma1.it.ORCID http://orcid.org/0000-0001-8433-9148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrinary symptoms represent a significant source of distress and disability in multiple sclerosis (MS), but the factors influencing their occurrence and exacerbation remain unclear. Frailty has been proposed as a measure of clinical complexity in MS and has been associated with its main phenotypic manifestations. The present study investigated the relationship between frailty and the presence and burden of urinary symptoms in MS. MATERIALS AND

methodsThe present study considered 149 outpatients. The presence of urinary symptoms was systematically explored. Frailty was assessed using a 40-item Frailty Index (FI). Participants with urinary symptoms underwent a urinary evaluation, including the 8-item overactive bladder questionnaire, the Urinary Incontinence Quality of Life Scale, Uroflowmetry, and Ultrasound for Postvoid Residual.

resultsThe mean disease duration was 13.7 years (SD 10.5), the median EDSS score was 1.5 (IQR = 0-3). Frailty was significantly associated with the presence and burden of urinary symptoms. Additionally, there was a positive correlation between the frailty index and chronological age, EDSS, disease duration, OAB, and I-QOL (all p < 0.05). In people with urinary symptoms, two multivariable logistic regression models showed that only the frailty index score was significantly associated with the Incontinence Quality of Life Scale total score and the 8-item overactive bladder questionnaire. No correlations were found between uroflowmetry data, postvoid residual, and frailty.

conclusionFrailty is associated with the presence and burden of disability due to urinary symptoms. Frailty possibly affects the pathophysiological mechanisms of MS involved in the development and worsening of urinary symptoms.

Indexed as

Disease ProgressionFrailtyMultiple SclerosisAdultFemaleHumansMaleMiddle AgedQuality of LifeFrailtyMultiple sclerosisQuality of lifeUrinary symptoms

Identifiers

PMID40100557

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