ArticleMedical physics2025
Total brain dose estimation in single-isocenter-multiple-targets (SIMT) radiosurgery via a novel deep neural network with spherical convolutions.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeAccurate prediction of normal brain dosimetric parameters is crucial for the quality control of single-isocenter multi-target (SIMT) stereotactic radiosurgery (SRS) treatment planning. Reliable dose estimation of normal brain tissue is one of the great indicators to evaluate plan quality and is used as a reference in clinics to improve potentially SIMT SRS treatment planning quality consistency. This study aimed to develop a spherical coordinate-defined deep learning model to predict the dose to a normal brain for SIMT SRS treatment planning.
methodsBy encapsulating the human brain within a sphere, 3D volumetric data of planning target volume (PTVs) can be projected onto this geometry as a 2D spherical representation (in azimuthal and polar angles). A novel deep learning model spherical convolutional neural network (SCNN) was developed based on spherical convolution to predict brain dosimetric evaluators from spherical representation. Utilizing 106 SIMT cases, the model was trained to predict brain V50%, V60%, and V66.7%, corresponding to V10Gy and V12Gy, as key dosimetric indicators. The model prediction performance was evaluated using the coefficient of determination (R
resultsThe SCNN accurately predicted normal brain dosimetric values from the modeled spherical PTV representation, with R
conclusionsThe deep learning model provides treatment planners with accurate prediction of dose to normal brain, enabling improved consistency in treatment planning quality. This method can be extended to other brain-related analyses as an efficient data dimension reduction method.
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