Evidence map›Paper›PMID 40100459›Full record

Observational studyInternational ophthalmology2025

The correlation of clinical and histopathological features of eyelid malignancies: a 5-year retrospective study in Vietnam.

Ngan-Ha Nguyen, Minh-Phu Nguyen, Hoa Kieu Mai, Son Truong Do, Van Hong Pham, Dung Thi Phuong Vuong, Jay R Maturi, Huong Vu Thuy Le, Peter Mc Cluskey, Van Trong Pham

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ngan-Ha NguyenDepartment of Ophthalmology, Hanoi Medical University, No1, Ton That Tung Street, Dong Da, Hanoi, Vietnam. nguyennganha@hmu.edu.vn.ORCID http://orcid.org/0000-0001-9336-5874
Minh-Phu NguyenDepartment of Pediatric Ophthalmology, Vietnam National Eye Hospital, Hanoi, Vietnam.
Hoa Kieu MaiDepartment of Ophthalmology, Hanoi Medical University, No1, Ton That Tung Street, Dong Da, Hanoi, Vietnam.
Son Truong DoDepartment of Ophthalmology, Hanoi Medical University, No1, Ton That Tung Street, Dong Da, Hanoi, Vietnam.
Van Hong PhamDepartment of Oculofacial Plastic and Cosmesis, Vietnam National Eye Hospital, Hanoi, Vietnam.
Dung Thi Phuong VuongDepartment of Ophthalmology, Nghe An General Hospital, Nghe An, Vietnam.
Jay R MaturiSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Huong Vu Thuy LeFred Hutch Cancer Center, Seattle, WA, USA.
Peter Mc CluskeyFaculty of Medicine and Health, Save Sight Institute, The University of Sydney, Sydney, NSW, Australia.
Van Trong PhamDepartment of Ophthalmology, Hanoi Medical University, No1, Ton That Tung Street, Dong Da, Hanoi, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze the correlation between the clinical and histopathological features of eyelid malignancies in Vietnam.

methodsAn observational retrospective study was conducted on 190 patients who were diagnosed histopathologically after surgery with eyelid malignancies between 2017 and 2021 at Vietnam National Eye Hospital. Demographic, clinical manifestations, pathological features and outcomes were analyzed.

resultsBasal cell carcinoma was the most common histopathologic type, accounting for 57.9% of cases, followed by sebaceous gland carcinoma at 27.4%. The match between clinical diagnosis and pathological diagnosis was 57.4% across all cases. The majority of basal cell carcinoma cases presented on the lower eyelid, while the majority of sebaceous gland carcinoma cases presented on the upper eyelid. Clinical features with the highest clinical correlation were ulceration (76.4%) for basal cell carcinoma and ill-defined edges (84.6%) among malignant cutaneous melanoma.

conclusionEyelid malignancies present significant challenges in clinical diagnosis, with only moderate concordance between clinical and histopathological findings. Basal cell carcinoma is the most common eyelid malignancy in Vietnam, though its incidence is significantly lower than in Western countries. Clinical findings with the most consistent clinical correlation were high rates of ulceration in basal cell carcinoma and ill-defined edges in malignant melanoma.

Indexed as

Basal Cell CarcinomaEyelid NeoplasmsEyelidsMelanomaAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedRetrospective StudiesTime FactorsVietnamClinical manifestationsEpidemiologyEyelid malignanciesHistopathological features

Identifiers

PMID40100459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.