Evidence map›Paper›PMID 40100457›Full record

ReviewCurrent atherosclerosis reports2025

Impact of Sex Differences on Lipids and Statin Utilization.

Carla P Rodriguez, Semenawit Burka, Erin D Michos

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carla P RodriguezDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Semenawit BurkaDivision of Cardiology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, USA.
Erin D MichosDivision of Cardiology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, USA. edonnell@jhmi.edu.

Funding

Robert Winn Career Development Award 147410The Amato Fund for Women's Cardiovascular Health 946222
6 · The paper itself

Abstract

purpose of the reviewHypercholesterolemia is a significant and modifiable risk factor for cardiovascular disease (CVD), with Low-Density Lipoprotein Cholesterol (LDL-C) being the primary target for lipid-lowering therapies in both primary and secondary prevention. This review aims to explore the efficacy of statin therapy in women, its safety and application during pregnancy, and treatment disparities that contribute to undertreatment of dyslipidemia in women. RECENT

findingsStatins has demonstrated efficacy in reducing LDL-C and CVD risk in women. However, women are less likely to achieve LDL-C targets compared to men, largely due to undertreatment and delays in initiating therapy, often influenced by sex-specific factors. The unique considerations of lipid management during pregnancy, including suspension of statin therapy, present additional challenges in achieving optimal lipid control in high-risk women. Evidence also points to systemic disparities in healthcare delivery and treatment allocation, further exacerbating undertreatment of dyslipidemia among women. While LDL-C lowering remains a cornerstone of CVD prevention, women face distinct challenges in achieving lipid goals due to biological, clinical, and healthcare disparities. Addressing these barriers, including improving timely initiation of statins and addressing gaps in care during pregnancy, is essential to enhance the dyslipidemia management and reduce CVD risk in women.

Indexed as

Cardiovascular DiseasesDyslipidemiasHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaCholesterol, LDLFemaleHumansMalePregnancyRisk FactorsSex FactorsCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsCardiovascular diseaseFamilial hypercholesterolemiaPregnancyPreventionStatinsWomen’s health

Identifiers

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.