Evidence map›Paper›PMID 40100449›Full record

ArticleMolecular biology reports2025

Bacteriological profile of diabetic foot ulcers and analysis of serum meteorin levels.

Esra Erdogan, Azize Yetisgen, Lezzan Keskin, Elif Seren Tanriverdi, Isilay Gokce Benk Ugur

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Esra ErdoganDepartment of Basic Pharmacy Sciences, Faculty of Pharmacy, Harran University, Sanliurfa, Türkiye. esraerdogan@harran.edu.tr.ORCID http://orcid.org/0000-0003-1626-6033
Azize YetisgenDepartment of Infectious Diseases, Malatya Training and Research Hospital, Malatya, Türkiye.ORCID http://orcid.org/0000-0003-4987-6612
Lezzan KeskinDepartment of Endocrinology, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye.ORCID http://orcid.org/0000-0001-8283-4516
Elif Seren TanriverdiDepartment of Medical Microbiology, Faculty of Medicine, Inonu University, Malatya, Türkiye.ORCID https://orcid.org/0000-0002-0449-0356
Isilay Gokce Benk UgurDepartment of Medical Microbiology, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye.ORCID http://orcid.org/0000-0002-8715-7873

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWith the increase in the incidence of diabetes mellitus (DM) in recent years, diabetic foot ulcers (DFU), which are common and serious chronic complications of diabetes, have also become widespread. DFU is highly associated with a significant deterioration in quality of life as well as increased morbidity and mortality. Meteorin is a potent neurotrophic growth factor and shows antiangiogenic, antihyperalgesic, antinociceptive and neuroprotective effects. This study aimed to determine the possible relationship between meteorin, diabetes and diabetic foot ulcer by comparing the serum meteorin levels of healthy control group, DM patients and patients with diabetic foot ulcers.

methodsOur study included a total of 62 diabetic patients, 31 of whom had DFU, and 29 healthy individuals as a control group. Meteorin levels of the participants were measured using ELISA method in serum samples. Other laboratory and epidemiological data of the patients were obtained from the hospital database.

resultsIn the wound cultures taken from patients with DFU, the most commonly isolated bacteria were Staphylococcus aureus and Pseudomonas aeruginosa. Serum meteorin levels were found to be statistically significantly higher in diabetic patients as compared to the healthy control group, and among diabetic patients, those with DFU had significantly higher levels compared to those without DFU. A positive significant correlation was found between meteorin level and age, HbA1c, WBC, urea, sedimentation, CRP and ferritin.

conclusionThe results of our study, aimed at better understanding the biological functions and potential clinical applications of meteorin, suggest that meteorin could potentially be used as a biomarker for the development of DFU.

Indexed as

Diabetic FootNerve Growth FactorsAdultAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedPseudomonas aeruginosaStaphylococcus aureusBiomarkersNerve Growth FactorsDiabetic foot ulcersMeteorinStaphylococcus aureusWagner classification

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.