Evidence map›Paper›PMID 40100406›Full record

ArticleClinical oral investigations2025

Correlation of preoperative 18F-FDG-PET/CT tumor staging and maximum standardized uptake values with preoperative CT, postoperative tumor classification, and histopathological parameters of oral squamous cell carcinoma.

Gunnar Müller, Daniel A Veit, Philipp Becker, Daniel G E Thiem, Peer W Kämmerer, Birte Diekmeyer, Richard Werkmeister, Diana Heimes, Andreas Pabst

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Gunnar Müller *Department of Pathology, German Armed Forces Central Hospital, Rübenacherstr. 170, 56072, Koblenz, Germany.
Daniel A Veit *Department of Nuclear Medicine, German Armed Forces Central Hospital, Rübenacherstr. 170, 56072, Koblenz, Germany.
Philipp BeckerDepartment of Oral and Maxillofacial Surgery, German Armed Forces Central Hospital, Rübenacherstr. 170, 56072, Koblenz, Germany.
Daniel G E ThiemDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Peer W KämmererDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Birte DiekmeyerDepartment of Nuclear Medicine, German Armed Forces Central Hospital, Rübenacherstr. 170, 56072, Koblenz, Germany.
Richard WerkmeisterDepartment of Oral and Maxillofacial Surgery, German Armed Forces Central Hospital, Rübenacherstr. 170, 56072, Koblenz, Germany.
Diana Heimes *Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Andreas Pabst *Department of Oral and Maxillofacial Surgery, German Armed Forces Central Hospital, Rübenacherstr. 170, 56072, Koblenz, Germany. andipabst@me.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to correlate preoperative 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) tumor staging, and maximum standardized uptake values (SUV MATERIAL AND

methodsThirty-seven OSCC patients staged via full-body 18F-FDG-PET/CT, including contrast agent CT of the head and neck in 2020 and 2021, were enclosed. Patients received tumor resection and stage-dependent neck dissection. Preoperative clinical (c) 18F-FDG-PET/CT UICC tumor stages and TNM classifications were correlated to corresponding CT and to postoperative histopathological (p) UICC tumor stages and TNM classifications. SUV

resultsComparing 18F-FDG-PET/CT and CT, cUICC, cT, and cN differed in 32.3%, 16.7%, and 37.8% of the cases, respectively. For 18F-FDG-PET/CT, a moderate correlation was found between c- and pUICC (0.494; p = 0.0018) with a misestimation of c- compared to pUICC in 43.2% of the cases. Comparing c- and pTNM, misestimations concerning c- and pT were seen in 51.4% and concerning c- and pN in 37.8% of the cases. An increased SUV

conclusionThe predictive value of 18F-FDG-PET/CT and SUV CLINICAL RELEVANCE: 18F-FDG-PET/CT can not unreservedly be recommended for primary OSCC staging. There is an urgent need to specify its indications in detail further.

Indexed as

Carcinoma, Squamous CellFluorodeoxyglucose F18Mouth NeoplasmsPositron Emission Tomography Computed TomographyRadiopharmaceuticalsTomography, X-Ray ComputedAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeck DissectionNeoplasm StagingPreoperative CareFluorodeoxyglucose F18Radiopharmaceuticals18F-FDG-PET/CTCTExtranodal extensionLymph node metastasesOral squamous cell carcinomaStagingSUVmaxTumor grading

Identifiers

PMID40100406

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