Evidence map›Paper›PMID 40100258›Full record

ArticleMicrobial genomics2025

Investigating two decades of

Ana D Sanches Ferreira, Alannah C King, Femke Wolters, Heiman F L Wertheim, Bert Mulder, Caroline M A Swanink, Christa E van der Gaast-de Jongh, Daan W Arends, Nina M van Sorge, Carel Schaars and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ana D Sanches FerreiraParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Alannah C KingParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Femke WoltersDepartment of Medical Microbiology, Radboudumc Center for Infectious Diseases, Nijmegen, The Netherlands.
Heiman F L WertheimDepartment of Medical Microbiology, Radboudumc Center for Infectious Diseases, Nijmegen, The Netherlands.
Bert MulderDicoon Laboratory, Elst & Department of Clinical Microbiology, Canisius-Wilhelmina Ziekenhuis, Nijmegen, The Netherlands.
Caroline M A SwaninkDepartment of Clinical Microbiology and Immunology, Rijnstate, Arnhem, The Netherlands.
Christa E van der Gaast-de JonghDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Daan W ArendsDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Nina M van SorgeNetherlands Reference Laboratory for Bacterial Meningitis, Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Carel SchaarsDepartment of Internal Medicine, Pantein Maasziekenhuis, Boxmeer, The Netherlands.
Harry C H HungParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Paulina A HawkinsDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, USA.
Lesley McGeeDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, USA.
Stephen D BentleyParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Jan-Willem VeeningDepartment of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Marien I de JongeDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Stephanie W LoParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Amelieke J H CremersDepartment of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Funding

Wellcome Trust
6 · The paper itself

Abstract

In the Netherlands, the 7-valent pneumococcal conjugate vaccine (PCV) was introduced to the childhood immunization programme in 2006 and replaced by the 10-valent PCV (PCV10, GSK) in 2011. To describe invasive pneumococcal disease in the era of childhood PCV vaccination on pneumococcal bacteraemia across all ages, we collected and sequenced 979 pneumococcal blood isolates from consecutive patients with pneumococcal bacteraemia in the Gelderland area, the Netherlands, between 2000 and 2020. In total, 58% of the bacteraemia cases (

Indexed as

BacteremiaPneumococcal InfectionsStreptococcus pneumoniaeWhole Genome SequencingAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsChildChild, PreschoolFemaleGenome, BacterialHumansInfantMaleAnti-Bacterial AgentsPneumococcal Vaccinesantimicrobial resistanceinvasive pneumococcal disease (IPD)pneumococcal conjugate vaccine (PCV)pneumococcal lineageserotypethe Netherlands

Identifiers

PMID40100258
PMCPMC11936379

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.