Evidence map›Paper›PMID 40100157›Full record

ArticleProtein science : a publication of the Protein Society2025

Templated trimerization of the phage L decoration protein on capsids.

Brianna M Woodbury, Rebecca L Newcomer, Makayla N Leroux, Andrei T Alexandrescu, Carolyn M Teschke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Templated trimerization of the phage L decoration protein on capsids.Protein science : a publication of the Protein Society · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Brianna M WoodburyDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Rebecca L NewcomerDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Makayla N LerouxDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Andrei T AlexandrescuDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0002-8425-9276
Carolyn M TeschkeDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0001-6420-4895

Funding

Understanding the Protein:Protein Interactions Required for Virus AssemblyR01GM076661 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI TESCHKE, CAROLYN M · 2007 to 2022
$7.2M
Investigating the conformational changes of the portal protein that drive DNA packaging in a dsDNA virusF31GM147952 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI LEROUX, MAKAYLA · 2023 to 2024
$92k
NIGMS NIH HHS F31 GM147952NIGMS NIH HHS R01 GM076661NIH HHS GM076661NIH HHS GM147952UConn Research Foundation
6 · The paper itself

Abstract

The 134-residue phage L decoration protein (Dec) forms a capsid-stabilizing homotrimer that has an asymmetric tripod-like structure when bound to phage L capsids. The N-termini of the trimer subunits consist of spatially separated globular OB-fold domains that interact with the virions of phage L or the related phage P22. The C-termini of the trimer form a spike structure that accounts for nearly all the interactions that stabilize the trimer. A Dec mutant with the spike residues 99-134 deleted (Dec

Indexed as

Bacteriophage P22CapsidCapsid ProteinsProtein MultimerizationViral ProteinsHydrogen-Ion ConcentrationModels, MolecularCapsid ProteinsViral Proteinsbacteriophagefolding reversibilitymetastable statemisfoldingvirus

Identifiers

PMID40100157
PMCPMC11917118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.