Evidence map›Paper›PMID 40100144›Full record

ArticleJournal of pediatric psychology2025

Minority stress, mental health, and substance use in transgender youth: the moderating role of positive affect.

Benjamin Parchem, Johnny Berona, Claire A Coyne, Judith T Moskowitz, Yee-Ming Chan, Diane Ehrensaft, Robert Garofalo, Marco A Hidalgo, Johanna Olson-Kennedy, Stephen M Rosenthal and 2 more

Abstract read
In one paragraph

Article in Journal of pediatric psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Benjamin ParchemPritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.
Johnny BeronaPritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.
Claire A CoynePritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.
Judith T MoskowitzDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Yee-Ming ChanDivision of Endocrinology, Boston Children's Hospital, Boston, MA, United States.
Diane EhrensaftDepartment of Pediatrics, Division of Pediatric Endocrinology, University of California San Francisco, San Francisco, CA, United States.
Robert GarofaloPotocsnak Family Division of Adolescent and Young Adult Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.ORCID 0000-0001-9513-9416
Marco A HidalgoDivision of Internal Medicine-Pediatrics & Preventive Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Johanna Olson-KennedyDivision of Adolescent and Young Adult Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.ORCID 0000-0001-6264-7596
Stephen M RosenthalDepartment of Pediatrics, Division of Pediatric Endocrinology, University of California San Francisco, San Francisco, CA, United States.
Amy C TishelmanDepartment of Psychiatry, Boston College, Chestnut Hill, MA, United States.ORCID 0000-0002-1467-1732
Diane ChenPritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.ORCID 0000-0002-7302-9248

Funding

The Impact of Early Medical Treatment in Transgender YouthR01HD082554 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI CHAN, YEE-MING, GAROFALO, ROBERT · 2015 to 2024
$9.7M
NUCATS CTSA K12 Program at Northwestern UniversityK12TR005104 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Leena Sharma, BETINA YANEZ · 2024 to 2026
$3.2M
Eunice Kennedy ShriverNCATS NIH HHS K12 TR005104NCATS NIH HHS K12TR005104NICHD NIH HHS R01 HD082554
6 · The paper itself

Abstract

objectiveTo examine the relationships between gender minority stressors and mental health outcomes among transgender and gender diverse (TGD) youth and explore the moderating role of positive affect.

methodBaseline data of 315 TGD youth (ages 12-20 years old) from the Trans Youth Care-United States study comprised the analytic sample. Youth completed three subscales of the Gender Minority Stress and Resilience Measure for Adolescents (GMSR-A; nondisclosure of gender identity/gender history, negative future expectations, and internalized transphobia), Beck Depression Inventory-II (BDI-II), Revised Children's Manifest Anxiety Scale, Second Edition (RCMAS-2), Alcohol, Smoking and Substance Involvement Screen Test (ASSIST), and the NIH Toolbox Positive Affect survey. Regression analyses using the Hayes PROCESS macro assessed moderation effects.

resultsGender minority stressors were associated with more symptoms of depression (r = 0.29 to 0.42) and anxiety (r = 0.32 to 0.42) and were not significantly associated with substance use (r = -0.01 to 0.10). Positive affect was negatively associated with gender minority stressors (r = -0.19 to -0.24) and mental health/substance use outcomes (r = -0.16 to -0.63). Positive affect significantly buffered the association between nondisclosure of gender identity and depressive symptoms (ΔR2 = 0.02) and protected against the impact of internalized transphobia on anxiety symptoms (ΔR2 = 0.01).

conclusionsPositive affect is a promising modifiable protective factor that buffers the negative impact of gender minority stress on the mental well-being of TGD youth. Adapting existing positive emotion interventions for TGD youth is an indicated future direction for research and clinical practice.

Indexed as

AffectAnxietyDepressionMental HealthSexual and Gender MinoritiesStress, PsychologicalSubstance-Related DisordersTransgender PersonsAdolescentChildFemaleHumansMaleUnited StatesYoung Adultadolescentsanxietydepressiongender minority stresspositive affect

Identifiers

PMID40100144
PMCPMC12112439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.