Evidence map›Paper›PMID 40099968›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Dietary effects on the retina of hamsters.

Nicole El-Darzi, Natalia Mast, Yong Li, Irina A Pikuleva

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Dietary effects on the retina of hamsters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicole El-DarziDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-2103-9492
Natalia MastDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-6427-640X
Yong LiDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Irina A PikulevaDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-9742-6232

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Significance of CYP46A1 and other P450s in retinal functionR01EY018383 · NEI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PIKULEVA, IRINA A · 2007 to 2024
$6.8M
Cholesterol Metabolizing P450s: Structure and FunctionR01AG067552 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI PIKULEVA, IRINA A · 2020 to 2024
$2.2M
HHS | NIH | National Eye Institute (NEI) EY011373HHS | NIH | National Eye Institute (NEI) EY018383NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY018383NIA NIH HHS R01 AG067552
6 · The paper itself

Abstract

The retina is a sensory tissue in the back of the eye, which captures visual information and relays it to the brain. The retinal pigment epithelium separates the neural retina from the choroidal (systemic) circulation and is thereby exposed to circulating lipoprotein particles. Herein, we used hamsters and conducted various retinal evaluations of animals fed either a normal diet or a Western-type diet (WTD). Prior to evaluations, hamsters were injected with indocyanine green (ICG), a fluorescent dye that binds to various proteins and lipids in the systemic circulation. The WTD increased plasma levels of total and HDL cholesterol 1.8- and 2.1-fold, respectively, and led to additional HDL

Indexed as

DietRetinaAnimalsCricetinaeIndocyanine GreenMaleMesocricetusMiceRetinal Pigment EpitheliumIndocyanine GreencholesteroldiethamsterHDLindocyanine greenlipoproteinretina

Identifiers

PMID40099968
PMCPMC11917192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.