Evidence map›Paper›PMID 40099963›Full record

ArticleJournal of cellular and molecular medicine2025

Identification of the Hub Gene LDB3 in Stanford Type A Aortic Dissection Based on Comprehensive Bioinformatics Analysis.

Xinyi Liu, Xing Liu, Bin Wan, Yipeng Ge, Haiou Hu, Hong Yu, Meng Zhao, Huadong Li, Junming Zhu

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In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xinyi LiuDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.ORCID 0000-0001-5587-4141
Xing LiuDepartment of Cardiovascular Surgery, Xinqiao Hospital of Army Medical University, Chongqing, China.ORCID 0000-0002-3068-6280
Bin WanMax Planck Insititute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Yipeng GeDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
Haiou HuDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
Hong YuDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Meng ZhaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Huadong LiDepartment of Cardiovascular Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Junming ZhuDepartment of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.

Funding

Capital's Funds for Health Improvement and Research CFH 2024-2-1053National Key Research and Development Program of China 2023ZD0504401
6 · The paper itself

Abstract

Stanford type A aortic dissection (TAAD) is a life-threatening disease. This study explored the role of LIM domain binding 3 (LDB3) in TAAD progression. Four datasets from the Gene Expression Omnibus were analyzed to identify TAAD-related hub genes. LDB3 single nucleotide polymorphisms (SNPs) were assessed in the UK Biobank. Western blotting and immunofluorescence detected LDB3 expression in angiotensin II (Ang II) stimulated human aortic vascular smooth muscle cells (HA-VSMC), human samples, and a murine model. Bioinformatics identified tissue inhibitor of metalloproteinase-1 (TIMP1) and LDB3 as TAAD hub genes. TIMP1 was expressed in macrophages, mesenchymal cells, and smooth muscle cells, while LDB3 was mostly expressed in smooth muscle cells. Validation showed TIMP1 was upregulated and LDB3 downregulated in TAAD. Six LDB3 SNPs were associated with aortic aneurysm and dissection in the UK Biobank. In human and murine samples, LDB3 expression was reduced in diseased tissues and co-localized with smooth muscle. Ang II-stimulated HA-VSMC exhibited LDB3 reduction and altered intercellular connections. The aforementioned findings suggest that the newly identified gene LDB3 is crucial in the progression of TAAD.

Indexed as

Adaptor Proteins, Signal TransducingAortic DissectionComputational BiologyLIM Domain ProteinsAngiotensin IIAnimalsDisease Models, AnimalGene Expression RegulationGenetic Predisposition to DiseaseHumansMaleMiceMuscle, Smooth, VascularMyocytes, Smooth MusclePolymorphism, Single NucleotideTissue Inhibitor of Metalloproteinase-1Adaptor Proteins, Signal TransducingAngiotensin IILIM Domain ProteinsTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1bioinformaticsdifferentially expressed genesLDB3single‐cell sequencingStanford type a aortic dissectionweighted gene coexpression network analysis

Identifiers

PMID40099963
PMCPMC11916769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.