Evidence map›Paper›PMID 40099927›Full record

ArticleProtein science : a publication of the Protein Society2025

A novel protein for bioremediation of gadolinium waste.

Harvey D Lee, Connor J Grady, Katie Krell, Cooper Strebeck, Aimen Al-Hilfi, Brianna Ricker, Melanie Linn, Nicole Y Xin, Nathan M Good, N Cecilia Martinez-Gomez and 1 more

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. A novel protein for bioremediation of gadolinium waste.Protein science : a publication of the Protein Society · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Harvey D LeeDepartment of Biomedical Engineering, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-4989-2655
Connor J GradyDepartment of Biomedical Engineering, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-3340-512X
Katie KrellDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.
Cooper StrebeckDepartment of Mechanical Engineering, Michigan State University, East Lansing, Michigan, USA.
Aimen Al-HilfiDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan, USA.ORCID 0009-0000-1044-3698
Brianna RickerDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-2216-9475
Melanie LinnDepartment of Small Animal Sciences, Michigan State University, East Lansing, Michigan, USA.
Nicole Y XinDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA.
Nathan M GoodDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA.ORCID 0000-0002-9490-5913
N Cecilia Martinez-GomezDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA.ORCID 0000-0002-4071-7204
Assaf A GiladDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-7272-7570

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Clinically Translatable MRI Reporter Genes and Imaging Methods with Ultra-High Specificity and SensitivityR01EB031008 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTIAN T FARRAR · 2021 to 2026
$4.0M
Bioengineering a novel electromagnetic perspective gene as a tool for wireless control of excitable cellsR01NS098231 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A, PELLED, GALIT · 2017 to 2021
$2.6M
Evolution and optimization of synthetic <READ/WRITE> function from and into cells using genetic programmingR01EB030565 · NIBIB · MICHIGAN STATE UNIVERSITY · PI BANZHAF, WOLFGANG, GILAD, ASSAF A · 2021 to 2024
$2.3M
Semi-synthetic, magneto-photonic circuit for non-invasive control of cellular functionR01EB031936 · NIBIB · CENTRAL MICHIGAN UNIVERSITY · PI GILAD, ASSAF A, HOCHGESCHWENDER, UTE H · 2021 to 2021
$2.0M
Molecular Imaging for Detection of Synthetic Biology Circuits, Oscillators and Toggle Switches in Regenerative MedicineR01NS104306 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A · 2018 to 2021
$1.3M
Michigan Economic Development CorporationNational Science Foundation 2027113NIBIB NIH HHS P41 EB024495NIBIB NIH HHS P41-EB024495NIBIB NIH HHS R01 EB030565NIBIB NIH HHS R01-EB030565NIBIB NIH HHS R01 EB031008NIBIB NIH HHS R01-EB031008NIBIB NIH HHS R01 EB031936NIBIB NIH HHS R01-EB031936NINDS NIH HHS R01 NS098231NINDS NIH HHS R01-NS098231NINDS NIH HHS R01 NS104306NINDS NIH HHS R01-NS104306
6 · The paper itself

Abstract

Several hundreds of tons of gadolinium-based contrast agents (GBCAs) are being dumped into the environment every year. Although macrocyclic GBCAs exhibit superior stability compared to their linear counterparts, we have found that the structural integrity of chelates is susceptible to ultraviolet light, regardless of configuration. In this study, we present a synthetic protein termed GLamouR that binds and reports gadolinium in an intensiometric manner. We then explore the extraction of gadolinium from MRI patient urine as a preventative measure for gadolinium pollution and investigate the viability of employing cost-effective bioremediation techniques for treating contaminated water bodies. Based on promising results, we anticipate proteins such as GLamouR can be used for detecting and mining rare earth elements beyond gadolinium and hope to expand the biological toolbox for such applications.

Indexed as

Contrast MediaGadoliniumProteinsWater Pollutants, ChemicalBiodegradation, EnvironmentalHumansMagnetic Resonance ImagingContrast MediaGadoliniumProteinsWater Pollutants, Chemicalbindingbioremediationgadoliniumgadolinium wastelanmodulinproteinrare earth elementsrare earths

Identifiers

PMID40099927
PMCPMC11915603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.