Evidence map›Paper›PMID 40099901›Full record

ArticleOrganic letters2025

Total Synthesis, Structure Elucidation, and Bioactivity Evaluation of the Cyclic Lipopeptide Natural Product Paenilipoheptin A.

Vladyslav Lysenko, Nataliia V Machushynets, Jisca L van Dam, Fabienne A C Sterk, Alexander Speer, Arthur F J Ram, Cornelis J Slingerland, Gilles P Van Wezel, Nathaniel I Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Exploring the Chemical Space ofOrganic letters · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vladyslav LysenkoBiological Chemistry Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.ORCID 0000-0001-9236-5821
Nataliia V MachushynetsMolecular Biotechnology Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.ORCID 0000-0002-8530-1966
Jisca L van DamFungal Genetics and Biotechnology Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.ORCID 0000-0002-7564-4711
Fabienne A C SterkBiological Chemistry Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Alexander SpeerDepartment of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centre, 1081 HZ, Amsterdam, The Netherlands.
Arthur F J RamFungal Genetics and Biotechnology Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Cornelis J SlingerlandBiological Chemistry Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Gilles P Van WezelMolecular Biotechnology Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.ORCID 0000-0003-0341-1561
Nathaniel I MartinBiological Chemistry Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.ORCID 0000-0001-8246-3006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we further investigated the structure of the recently reported cyclic lipopeptide natural product paenilipoheptin A. Here, we disclose the first total synthesis of the compound, allowing for its complete structural assignment. The route developed employs automated SPPS, providing access to the compound in quantities suitable for antibacterial and antifungal testing. These studies unequivocally establish the stereochemical framework of paenilipoheptin A and further reveal that the compound possesses moderate activity against Gram-positive bacteria.

Indexed as

Anti-Bacterial AgentsBiological ProductsLipopeptidesMicrobial Sensitivity TestsAntifungal AgentsGram-Positive BacteriaMolecular StructurePeptides, CyclicStereoisomerismAnti-Bacterial AgentsAntifungal AgentsBiological ProductsLipopeptidesPeptides, Cyclic

Identifiers

PMID40099901
PMCPMC11959586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.