Evidence map›Paper›PMID 40099873›Full record

ArticleProtein science : a publication of the Protein Society2025

Kingfisher: An open-sourced web-based platform for the analysis of hydrogen exchange mass spectrometry data.

Nolan K McLaughlin, Juan P Rincon Pabon, Samantha Gies, Reza Dastvan, Michael L Gross

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nolan K McLaughlinDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri, USA.
Juan P Rincon PabonDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-4269-7363
Samantha GiesDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
Reza DastvanDepartment of Biochemistry and Molecular Biology, St. Louis University, St. Louis, Missouri, USA.
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-1159-4636

Funding

NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLSR01GM131008 · NIGMS · WASHINGTON UNIVERSITY · PI MICHAEL L GROSS, Weikai Li · 2019 to 2026
$3.8M
Mass Spectrometry-Based Protein Footprinting: A New Tool for Amyloid Protein AggregationR01AG079283 · NIA · WASHINGTON UNIVERSITY · PI MICHAEL L GROSS · 2024 to 2026
$2.2M
Novel molecular mechanism for extracellular release of proteins implicated in metastatic cancerR37CA265877 · NCI · SAINT LOUIS UNIVERSITY · PI Reza Dastvan · 2022 to 2026
$2.1M
NCI NIH HHS R37 CA265877NIA NIH HHS R01 AG079283NIGMS NIH HHS R01 GM131008NIH HHS 1R01GM131008NIH HHS R01AG079283NIH HHS R37CA265877
6 · The paper itself

Abstract

Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is now a critical tool in molecular biology and structural proteomics. It is routinely used to probe protein and conformational dynamics through a well-established experiment where amide hydrogens exchange with deuterium atoms in a buffer containing D

Indexed as

Hydrogen Deuterium Exchange-Mass SpectrometryInternetProteinsSoftwareProteinsHDX statisticshydrogen–deuterium exchange mass spectrometryopen‐source softwareproteinR programmingstructural proteomics

Identifiers

PMID40099873
PMCPMC11915630

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.