Evidence map›Paper›PMID 40099854›Full record

ArticleProtein science : a publication of the Protein Society2025

Affinity-stability trade-off mechanism of residue 35 in framework region 2 of V

Koichi Yamamoto, Satoru Nagatoishi, Ryo Matsunaga, Makoto Nakakido, Daisuke Kuroda, Kouhei Tsumoto

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Affinity-stability trade-off mechanism of residue 35 in framework region 2 of VProtein science : a publication of the Protein Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Koichi YamamotoDepartment of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
Satoru NagatoishiThe Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ryo MatsunagaDepartment of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7702-9176
Makoto NakakidoDepartment of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0328-9914
Daisuke KurodaDepartment of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
Kouhei TsumotoDepartment of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.

Funding

Japan Agency for Medical Research and Development JP223fa627001Japan Agency for Medical Research and Development JP223fa727002Japan Agency for Medical Research and Development JP23ama121033Japan Society for the Promotion of Science JP19H05766Japan Society for the Promotion of Science JP20H02531
6 · The paper itself

Abstract

Single-domain V

Indexed as

Antibody AffinityAntigensImmunoglobulin Heavy ChainsModels, MolecularProtein Structure, QuaternaryProtein Structure, TertiaryTemperatureAntigensImmunoglobulin Heavy Chainsbinding affinityCDR3FR2position 35thermal stabilityVHH antibody

Identifiers

PMID40099854
PMCPMC11915348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.