Evidence map›Paper›PMID 40099850›Full record

ArticleJournal of the International Neuropsychological Society : JINS2025

Interactive effects of post-traumatic stress disorder symptom severity and hypertension on cognitive dispersion in older Vietnam-Era veterans with history of post-traumatic stress disorder.

Uriel A Urias, Kelsey R Thomas, Alexandra J Weigand, Maria Bordyug, Amanda Gonzalez, Britney Luu, Alin Alshaheri Durazo, Mary Ellen Garcia, Katherine J Bangen, Department of Defense Alzheimer’s Disease Neuroimaging Initiative

Abstract read
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In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Uriel A UriasDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Kelsey R ThomasVA San Diego Healthcare System, San Diego, CA, USA.
Alexandra J WeigandSan Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Maria BordyugDepartment of Psychiatry, University of California, San Diego, CA, USA.
Amanda GonzalezDepartment of Psychiatry, University of California, San Diego, CA, USA.
Britney LuuDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Alin Alshaheri DurazoDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Mary Ellen GarciaVA San Diego Healthcare System, San Diego, CA, USA.
Katherine J BangenVA San Diego Healthcare System, San Diego, CA, USA.ORCID https://orcid.org/0000-0002-1363-3179
Department of Defense Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI JOHNSON, DAVID K · 1991 to 2020
$28.3M
SDSU ADAR ProgramR25AG043364 · NIA · SAN DIEGO STATE UNIVERSITY · PI THEREASA A CRONAN · 2013 to 2026
$5.5M
Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetesR01AG063782 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGEN, KATHERINE · 2020 to 2024
$3.7M
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495k
NIA NIH HHS K01 AG030514NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG063782NIA NIH HHS R25 AG043364NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

objectivePost-traumatic stress disorder (PTSD) and hypertension are highly prevalent among Veterans. Cognitive dispersion, indicating within-person variability across neuropsychological measures at one time point, is associated with increased risk of dementia. We examined interactive effects of PTSD symptom severity and hypertension on cognitive dispersion among older Veterans.

methodsWe included 128 Vietnam-era Veterans from the Department of Defense-Alzheimer's Disease Neuroimaging Initiative (DoD-ADNI) with a history of PTSD. Regression models examined interactions between PTSD symptom severity and hypertension on cognitive dispersion (defined as the intraindividual standard deviation across eight cognitive measures) adjusting for demographics and comorbid vascular risk factors.

resultsThere was an interaction between PTSD symptom severity and hypertension on cognitive dispersion (

conclusionsFindings suggest, among older Veterans with PTSD, those with both hypertension and more severe PTSD symptoms may be at greater risk for cognitive difficulties. Further, cognitive dispersion may be a useful marker of subtle cognitive difficulties. Future research should examine these associations longitudinally and in a diverse sample.

Indexed as

Alzheimer’s diseasecognitive dispersionhypertensionIntraindividual variabilitypost-traumatic stress disorderveterans

Identifiers

PMID40099850
PMCPMC12221303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.