ArticleDiagnostic and interventional radiology (Ankara, Turkey)2025
Dual-energy computed tomography-based volumetric thyroid iodine quantification: correlation with thyroid hormonal status, pathologic diagnosis, and phantom validation.
Article in Diagnostic and interventional radiology (Ankara, Turkey), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Assessment of thyroid iodine accumulation following repeated iodinated contrast media administration using dual-energy computed tomography in a rabbit model.Scientific reports · 2026Article
- Prediction of thyroid function based on CT radiomics: a two-center study.Quantitative imaging in medicine and surgery · 2025Article
- Letter to editor: dual-energy computed tomography-based volumetric thyroid iodine quantification: correlation with thyroid hormonal status, pathologic diagnosis, and phantom validation.Diagnostic and interventional radiology (Ankara, Turkey) · 2025Article
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Abstract
purposeTo investigate the relationship between intrathyroidal iodine concentration (IC) (mg I/mL) and thyroid hormonal status or pathologic diagnosis with the use of dual-energy computed tomography (DECT).
methodsWe retrospectively included patients who underwent neck CT examination between September 2016 and August 2021 using a dual-layer DECT scanner (120 kilovolt peak) for preoperative thyroid imaging. We performed volumetric IC measurements at the thyroid parenchyma on the additional iodine map generated from non-contrast images. We then compared the mean IC of thyroid parenchyma based on thyroid hormonal status (hypothyroid, euthyroid, and hyperthyroid) and diffuse thyroid disease (DTD). Additionally, we determined the accuracy of iodine quantification with our site-specific DECT acquisition protocol using a Gammex
resultsAmong the 578 patients (M:F: 87:491, age: 48.6 ± 11.7 years) who were finally selected, the mean thyroid parenchymal ICs was the lowest in the hyperthyroid group, followed by the hypothyroid group, and then the euthyroid group (0.68 ± 0.37, n = 44 vs. 1.13 ± 0.42, n = 61 vs. 1.32 ± 0.43, n = 473,
conclusionDECT-based IC quantification could be a potentially useful method for identifying patients with thyroid hormone dysfunction or DTD without the use of contrast media. CLINICAL SIGNIFICANCE: Without the need for intravenous administration, DECT-based intrathyroidal IC quantification provides potentially valuable information from the non-contrast CT image of the thyroid parenchyma.
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