Evidence map›Paper›PMID 40099670›Full record

ArticleAndrology2025

Is 'living apart together' a real advantage for patients consulting for sexual dysfunction? A cohort study.

Clotilde Sparano, Giovanni Corona, Giulia Rastrelli, Linda Vignozzi, Daniele Vignoli, Mario Maggi

Abstract read
In one paragraph

Article in Andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Positive demography: changing the perspective on population aging from the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clotilde SparanoEndocrinology Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.ORCID 0000-0002-3766-4682
Giovanni CoronaEndocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy.ORCID 0000-0002-9894-2885
Giulia RastrelliAndrology, Women's Endocrinology and Gender Incongruence Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.ORCID 0000-0002-6164-4278
Linda VignozziAndrology, Women's Endocrinology and Gender Incongruence Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.ORCID 0000-0003-0907-0630
Daniele VignoliDepartment of Statistics, Computer Science, Applications, University of Florence, Florence, Italy.ORCID 0000-0003-1227-5880
Mario MaggiEndocrinology Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.ORCID 0000-0003-3267-4221

Funding

Next Generation EU DM 1557 11.10.2022
6 · The paper itself

Abstract

backgroundQuantitative research on families has introduced a new category of relationship called living apart together, that is, when a couple in a committed relationship live in separate homes. This study aimed to confirm whether living apart together improves sexual relationships in those suffering from sexual dysfunction.

methodsThis study comprised cross-sectional (N = 4852) and longitudinal (N = 1402) analyses. The former explored psychobiological, hormonal and relational correlates using the Structured Interview on Erectile Dysfunction scale. The latter assessed the occurrence of major adverse cardiovascular events in a subset of patients followed for 4.3 ± 2.59 years.

resultsCompared to cohabiting couples, patients in living apart together relationships were younger and characterised by higher education levels, healthier lifestyles and lower comorbidity burdens (all p < 0.001). After adjusting for those confounders, the living apart together group reported better sexual functioning, more frequent sexual intercourse, and higher total testosterone levels (p < 0.001), and the relationship was often a source of conflicts within the familial context and of shorter duration (all p < 0.05). When total testosterone was included in a fully adjusted analysis of covariance, the difference in obtaining a full erection between cohabiting and living apart together relationships became non-significant (p = 0.086), suggesting a hormonal influence on erectile dysfunction. In the longitudinal analysis, Cox models adjusted for the aforementioned confounders showed that living apart together relationships are associated with a twofold greater risk of major adverse cardiovascular events than cohabiting relationships, independent of other risk factors, including total testosterone levels, waist circumference and pathological penile blood flow. DISCUSSION: This study illustrates that partnership arrangements can shape sexual interest and complaints, as reported by the participants. While men involved in living apart together relationships show an ostensibly healthier phenotype, they experienced more often major adverse cardiovascular events. Therefore, co-residential relationship appears to provide more effective protection against future major adverse cardiovascular events for the male partner than a living apart together relationship.

Indexed as

Erectile DysfunctionSexual BehaviorSexual Dysfunction, PhysiologicalAdultAgedCross-Sectional StudiesHumansLongitudinal StudiesMaleMiddle AgedTestosteroneTestosteroneageingcardiovascular diseaseerectile dysfunctionLATlife styletestosterone

Identifiers

PMID40099670
PMCPMC12569729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.