Evidence map›Paper›PMID 40099656›Full record

ArticleNanomedicine (London, England)2025

3D spheroid model reveals enhanced efficacy of mannose-decorated nanoparticles for TB treatment.

Suyash M Patil, Apoorva Daram, Nitesh K Kunda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mannosamine-Modified Poly(lactic-Bioconjugate chemistry · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suyash M PatilDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, New York, NY, USA.
Apoorva DaramDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, New York, NY, USA.
Nitesh K KundaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTuberculosis (TB), caused by

methodsWe explored a combination therapy using bedaquiline and pretomanid encapsulated in polymeric nanoparticles (pNPs). Further, active targeting was achieved through mannose-decorated nanoparticles (Man-pNPs) for macrophage-specific delivery. The drug-loaded pNPs and Man-pNPs were spray-dried into dry powder particles to improve drug solubility and enable local lung delivery

resultsFormulations exhibited high drug loading and excellent aerosolization performance (MMAD 1-5 µm, FPF > 75%) for pNPs and Man-pNPs. Man-pNPs formulation enhanced macrophage targeting

conclusionThis research underscores the potential of combination therapy, particulate-based inhaled drug delivery, and active targeting to advance efficient and patient-friendly TB treatments.

Indexed as

Antitubercular AgentsMannoseNanoparticlesTuberculosisAnimalsDiarylquinolinesDrug Delivery SystemsHumansMacrophagesMiceMicrobial Sensitivity TestsMycobacterium tuberculosisPhagocytosisSpheroids, CellularAntitubercular AgentsbedaquilineDiarylquinolinesMannoseBedaquilinemannose targetingPLGA nanoparticlesPretomanidTuberculosis

Identifiers

PMID40099656
PMCPMC11988228

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.