ArticleMovement disorders : official journal of the Movement Disorder Society2025
Long-Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts.NPJ Parkinson's disease · 2026Article
- The Place of Adaptive Deep Brain Stimulation in Parkinson's Disease: Spatial before Temporal Optimization.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states.bioRxiv : the preprint server for biology · 2026Article
- Multimodal Image Guidance in Subthalamic Deep Brain Stimulation for Parkinson's Disease.Annals of neurology · 2026Article
- Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Identifying maximal beta power from directional subthalamic local field potentials in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Pallidal alpha activity is an electrophysiological biomarker of symptom severity in obsessive-compulsive disorder.Research square · 2026Article
- Beta-Band and Aperiodic Activity Across New and Chronic Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Proceedings of the 13th annual deep brain stimulation think tank: the evolving landscape.Frontiers in human neuroscience · 2026Review
- Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.EBioMedicine · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundSubthalamic beta oscillations are a biomarker for bradykinesia and rigidity in Parkinson's disease (PD), incorporated as a feedback signal in adaptive deep brain stimulation with potential for guiding electrode contact selection. Understanding their longitudinal stability is essential for successful clinical implementation.
objectivesWe aimed to analyze the long-term dynamics of beta peak parameters and beta power distribution along electrodes.
methodsWe recorded local field potentials from 12 channels per hemisphere of 33 PD patients at rest, in a therapy-off state at two to four sessions (0, 3, 12, 18-44 months) post-surgery. We analyzed bipolar beta power (13-35 Hz) and estimated monopolar beta power in subgroups with consistent recordings.
resultsDuring the initial 3 months, beta peak power increased (P < 0.0001). While detection of high-beta peaks was more consistent, low- and high-beta peak frequencies shifted substantially in some hemispheres during all periods. Spatial distribution of beta power correlated over time. Maximal beta power across segmented contact levels and directions was significantly stable compared with chance and increased in stability over time. Active contacts for therapeutic stimulation showed consistently higher normalized beta power than inactive contacts (P < 0.0001).
conclusionsOur findings indicate that beta power is a stable chronic biomarker usable for beta-guided programming. For adaptive stimulation, high-beta peaks might be more reliable over time. Greater stability of beta power, center frequency, and spatial distribution beyond an initial stabilization period suggests that the microlesional effect significantly impacts neuronal oscillations, which should be considered in routine clinical practice when using beta activity for automated programming algorithms. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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