ArticleJournal of cosmetic dermatology2025
The Role of the Major Histocompatibility Complex Region on Chromosome 6 in Skin Atrophy: A Mendelian Randomization Study.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Integrated Genomic and GEO Data Analysis Reveals Therapeutic Targets for Rosacea.Journal of cosmetic dermatology · 2025Article
- The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study.Nature and science of sleep · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundSkin atrophy (SA) is a pathological condition marked by the thinning of the skin, decreased elasticity, and reduced functionality, often arising from aging, chronic glucocorticoid use, or autoimmune diseases.
objectiveThis study investigates the role of the major histocompatibility complex (MHC) region on chromosome 6 in the development of SA.
methodsWe applied summary-data-based Mendelian randomization (SMR) using eQTL data of three skin-related tissues (whole blood, lower leg, and suprapubic) from the GTEx database, and SA genome-wide association study data from FinnGen. Further, we conducted functional enrichment, colocalization, and drug enrichment analyses on the core genes (intersection genes) to explore their functions and druggability.
resultsSix core genes (PSORS1C3, HLA-C, HLA-DRB5, HLA-DRB6, HLA-DQA1, and HLA-DQB1) located on chromosome 6p21 were consistently identified across all tissues. Functional enrichment, pathway, and protein-protein interaction analyses revealed that these genes are involved in antigen processing and immune response regulation. Drug enrichment analysis highlighted potential therapeutic targets, including interactions with palladium, azathioprine, and insulin. However, limitations in available data for PSORS1C3 and HLA-DRB6, as well as inconclusive colocalization results, suggest a need for further research.
conclusionThis study highlights the involvement of six core genes within the MHC region on chromosome 6 in the development of SA, emphasizing their roles in immune regulation and antigen presentation. These findings open new avenues for understanding SA and offer a foundation for future investigations into immune-related pathways in skin diseases.
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Registered trials
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