ReviewFrontiers in cardiovascular medicine2025
Crosstalk between lipid metabolism and macrophages in atherosclerosis: therapeutic potential of natural products.
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Identifying Choroidal Neovascularization-Associated Genes with GenePlexus in a Protein-Protein Interaction Network.Life (Basel, Switzerland) · 2026Article
- Macrophage microRNAs integrating lipid metabolism and inflammation: Implications for atherosclerosis.Metabolism open · 2026Review
- Sequential pattern transformer (SPT): a generative and interpretable framework for predicting disease trajectories.Neural computing & applications · 2026Article
- LncRNA H19 drives atherosclerosis progression via the miR-let-7a/ITGB3 axis.Frontiers in physiology · 2026Article
- Vitamin D status and Its association with haematological inflammatory indices and cardiometabolic risk profiles: a retrospective cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Fatty acid binding protein 4 as a diagnostic biomarker for peripheral arterial disease in type 2 diabetes: a cross-sectional study.BMC cardiovascular disorders · 2025Observational
- Cyclodextrin: Dual Functions as a Therapeutic Agent and Nanocarrier for Regulating Cholesterol Homeostasis in Atherosclerosis.Pharmaceutics · 2025Review
- Comparative Pharmacokinetics of Five Major Ingredients in Normal and Atherosclerotic Rats after Oral Administration of Shenlian Formula.Current drug metabolism · 2025Article
- Mediating Role of Lipid Accumulation Products (LAP) in the Association of WBC with MASLD: SWH 2021-2023.Journal of inflammation research · 2025Article
- SPHK1-mediated M2 macrophage polarization drives TGF-β1-dependent thrombus fibrosis.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is a highly prevalent cardiovascular condition that affects individuals worldwide. Despite ongoing research into its treatment and prevention, atherosclerotic cardiovascular disease continues to exhibit high morbidity and mortality rates. The accumulation of low-density lipoprotein cholesterol is considered a major contributor to the development of atherosclerosis, with abnormalities in lipid metabolism playing a significant role in its pathogenesis. Lipid metabolism and macrophage function are intricately interconnected, with lipid metabolism being influenced by macrophage inflammatory responses, while macrophage activity is regulated by alterations in lipid metabolism. The interaction between these two processes plays a critical role in the progression of atherosclerosis. Natural products have shown considerable promise in treating a variety of diseases, including atherosclerosis. Moreover, the modulation of lipid metabolism and macrophage crosstalk represents a key mechanism through which natural products may exert their effects. This research aims to provide new insights into the current state of research on the role of natural products in regulating this pathway and the interplay between lipid metabolism and macrophages in the context of atherosclerosis, offering potential directions for the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.