ArticleInternational journal of women's health2025
Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- IGF1 is Reduced in Pregnancies with Preeclampsia and its Influence on Biological Behavior of Trophoblast Cells.Biochemical genetics · 2026Article
- Does a Biochemical Approach Facilitate the Diagnosis of Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder in Neonatal Period?International journal of molecular sciences · 2026Review
- Trophoblast Function in Preeclampsia: Decoding the Mechanistic Roles of Coding and Non-Coding Genes.International journal of molecular sciences · 2025Review
- Systemic and Local Immunological Markers in Preeclampsia.Diagnostics (Basel, Switzerland) · 2025Article
- The role of placental hormones and metabolites in modulating uterine circulation in physiological and pathological pregnancies.Frontiers in endocrinology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-1 receptor (IGF-1R) in the serum and placenta of patients with preeclampsia (PE), establish their correlations, and evaluate their diagnostic potential. Methods: 22 PE patients and 22 normal pregnant women who underwent cesarean section deliveries at the First Affiliated Hospital of Guangxi Medical University between December 2021 and December 2022 were included in the observation group and the control group. Enzyme-linked immunosorbent assay (ELISA) was utilized to measure the levels of IGF-1 and IGF-1R in serum samples, and immunohistochemical techniques (IHC) were employed to evaluate the levels of IGF-1 and IGF-1R in placental samples. The association between IGF-1, IGF-1R, and PE was analyzed, and the diagnostic accuracy of serum IGF-1 and IGF-1R for PE was assessed by ROC curve analysis. Results: The levels of IGF-1 and IGF-1R in the serum and average optical density (AOD) value of IGF-1 and IGF-1R in placental tissue of the observation group were significantly lower. In the group with PE, there was a reduction in the number of positive cells for IGF-1 and IGF-1R in placental tissue. Positive correlations were noted between IGF-1 and IGF-1R levels in both serum and placental tissue and neonatal birth weight. The ROC curve analysis revealed that serum IGF-1 exhibited an AUC of 0.944 for diagnosing PE, with a sensitivity of 86.00% and specificity of 100.00%. Serum IGF-1R showed an AUC of 0.820 for diagnosing PE, with a sensitivity of 77.00% and specificity of 77.00%. Conclusion: The expression of IGF-1 and IGF-1R in the serum and placental tissues of preeclamptic pregnant women was significantly reduced. This reduction implies that IGF-1 and IGF-1R may potentially be used as biomarkers in the clinical prediction, diagnosis, and prognosis evaluation of PE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.