ArticleFrontiers in microbiology2025
A comprehensive analysis of the genomic and proteomic profiles of a megalocytivirus isolated from
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparative Genomics-Guided Epitope Prioritization and in Silico Design of a Multi-Epitope DNA Vaccine Candidate Against Megalocytivirus pagrus 1.Marine biotechnology (New York, N.Y.) · 2026Article
- Genomic Analysis of Megalocytivirus Genomes Reveals Widespread Recombination.Genome biology and evolution · 2026Article
- Transcriptional and Alternative Splicing Regulation of Autophagy and Vesicle Transport Pathways in Large Yellow Croaker Cells During Megalocytivirus Infection.Animals : an open access journal from MDPI · 2026Article
- Genomic analysis ofbioRxiv : the preprint server for biology · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The prevalence of viral diseases has posed significant challenges to the sustainable development of large yellow croaker ( Methods: Viral DNA was sequenced using the Illumina HiSeq 2000 platform. Viral proteins from purified virions and supernatants of viral infected cells were subjected to LC-MS/MS analysis, and the expression of four viral proteins was further confirmed by Western blotting. The entire viral genome was subjected to phylogenetic and bioinformatic analyses. Results: The FD201807 genome comprises 112,214 bp of double-stranded DNA with a G + C content of 53.53%. It contains 130 potential open reading frames, with coding capacities ranging from 41 to 1,293 amino acids. Phylogenetic analysis of the whole-genome sequence indicated that the closest known megalocytivirus related to FD201807 is Pompano iridovirus, with a sequence identity of 98.98%. Label-free proteomics analysis identified 27 viral proteins in the viral-infected cell culture supernatants and 46 viral proteins in the purified virus of FD201807. Among these, 19 viral proteins were detected in both the viral-infected cell culture supernatants and the purified virus samples, while 8 viral proteins were exclusively identified in the viral-infected cell culture supernatants. Notably, there were two proteins derived from the cultured cell line MFF-1 (mandarin fish fry cell line-1), namely cytochrome c and ubiquitin-activating enzyme E1, present in both the purified virus samples and the culture supernatant of infected cells. These cellular proteins may be associated with virus-host protein interactions and/or host cell apoptosis. Discussion: We present the most comprehensive proteomic analysis to date of the megalocytivirus isolated from
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