ArticleCureus2025
Clinical Profile and Long-Term Outcomes of Scrub Typhus Meningoencephalitis in Children.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Meningoencephalitis in Flea-Borne Typhus: A Report of Two Cases and a Review of CNS Complications.Pathogens (Basel, Switzerland) · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionScrub typhus is a significant cause of acute encephalitis syndrome (AES) in pediatric populations, particularly in northern India. Its long-term outcomes have not been well studied to date. This study investigates the clinical profile and long-term outcomes of scrub typhus meningoencephalitis in children.
methodsThis prospective observational study was conducted at King George's Medical University, Uttar Pradesh, India, from August 2018 to October 2020. Children aged 0.3 months to 14 years who presented with AES were tested for scrub typhus using serum IgM Enzyme-Linked Immunosorbent Assay (ELISA) and polymerase chain reaction (PCR) of cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC). Positive patients were followed up for one year to assess long-term neurological outcomes.
resultsOf 264 children tested for scrub typhus, 78 (29.5%) were positive. Neurological symptoms included altered sensorium (70 (89.74%)), seizures (69 (88.46%)), and focal neurological deficits 8 (10.26%). Hepato-splenomegaly (27 (34.61%)), thrombocytopenia (48 (61.5%)), and raised liver transaminases (51 (65.4%)) were the other common manifestations. Mortality occurred in 10.25% of cases. Sixty-seven cases were followed up for one year. Long-term outcomes indicated that 60 (89.55%) of the patients fully recovered, while seven (10.45%) experienced sequelae, including minor impairment in four (5.97%), moderate impairment in two (2.99%), and severe impairment in one case (1.49%).
conclusionScrub typhus is a major cause of AES in children, with significant neurological sequelae in a small number of cases.
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