Evidence map›Paper›PMID 40099044›Full record

ArticleClinical, cosmetic and investigational dermatology2025

Effectiveness and Safety of the Use of 1470 nm Laser Therapy in Patients Suffering From Acne Scarring of the Facial Skin.

Paweł Kubik, Stefano Bighetti, Luca Bettolini, Wojciech Gruszczyński, Bartłomiej Łukasik, Stefania Guida, Giorgio Stabile, Elisa Maria Murillo Herrera, Andrea Carugno, Edoardo D'Este and 1 more

Abstract read
In one paragraph

Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Fractional COPostepy dermatologii i alergologii · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paweł KubikMedical Department, K-LAB Badania i Rozwój, Gdynia, Poland.ORCID 0000-0002-1229-5286
Stefano BighettiDermatology Department, University of Brescia, Brescia, Italy.ORCID 0009-0006-2781-6909
Luca BettoliniDermatology Department, University of Brescia, Brescia, Italy.ORCID 0000-0003-4374-802X
Wojciech GruszczyńskiMedical Department, K-LAB Badania i Rozwój, Gdynia, Poland.ORCID 0009-0005-5609-8435
Bartłomiej ŁukasikMedical Department, Matex Laboratory Switzerland SA, Geneve, Switzerland.ORCID 0009-0006-3646-5143
Stefania GuidaDermatology Unit, Università Vita-Salute San Raffaele, Milan, Italy.ORCID 0000-0002-8221-6694
Giorgio StabileDermatology Unit, Università Vita-Salute San Raffaele, Milan, Italy.ORCID 0000-0002-6935-8145
Elisa Maria Murillo HerreraMedical Department, Centro Avanzado de Dermatologia Y Laser, San Pedro Sula, Honduras.
Andrea CarugnoDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.ORCID 0000-0002-8231-2205
Edoardo D'EsteDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.ORCID 0009-0005-2545-1013
Nicola ZerbinatiDepartment of Medicine and Technology Innovation, University of Insubria, Varese, Italy.ORCID 0000-0003-2177-9677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This prospective, single-center, open-label study aimed to evaluate the efficacy and safety of 1470 nm non-ablative laser therapy in treating facial acne scars. The primary objective was to assess improvements in skin texture, elasticity, and scar depth and diameter, while confirming the absence of significant adverse effects. Patients and Methods: 40 healthy female volunteers aged 18 to 42 years with facial acne scars underwent three sessions of 1470 nm laser therapy at two-week intervals. Outcome measures included cutometric assessments, high-frequency ultrasound evaluations, and clinical photographic documentation, conducted at baseline and on days 21, 42, 70, and 130 post-treatment. Results: Significant improvements were observed across all evaluated parameters. Skin elasticity increased progressively from baseline (mean: 62.95, SD=4.0) to day 21 (63.72, SD=3.8, +4%), day 42 (67.11, SD=4.0, +6%), day 70 (69.08, SD=4.2, +11%), and day 130 (70.80, SD=4.4, +14%; p<0.001). High-frequency ultrasound measurements revealed substantial reductions in scar depth, which decreased by 5% at day 21 (mean: 0.18 mm, SD=0.05, p<0.001), 20% at day 42 (0.15 mm, SD=0.055, p<0.001), 48% at day 70 (0.10 mm, SD=0.06, p<0.001), and 63% at day 130 (0.07 mm, SD=0.065, p<0.001). Scar diameter followed a similar trend, with reductions of 16% at day 21 (3.08 mm, SD=0.3, p<0.001), 26% at day 42 (2.71 mm, SD=0.34, p<0.001), 42% at day 70 (2.13 mm, SD=0.36, p<0.001), and 62% at day 130 (1.39 mm, SD=0.38, p<0.001). Clinical photographic evaluations corroborated these quantitative findings, showing visible improvements in scar appearance and overall skin texture. No adverse events were reported throughout the study. Conclusion: The 1470 nm non-ablative laser therapy demonstrated high efficacy and safety in the treatment of acne scars, delivering substantial therapeutic benefits and high patient satisfaction, offering a valuable therapeutic option for addressing both pigmentation and textural issues associated with acne scars.

Indexed as

1470 nm laser therapyacne scarsnon-ablative laserscar reductionskin elasticity

Identifiers

PMID40099044
PMCPMC11911818

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.