ArticleRespirology case reports2025
The Potential of Pulmonary Vasodilators as a Bridging Therapy for Lung Transplantation: Two Cases of Interstitial Pneumonia With Pulmonary Hypertension During the Waiting Period for Lung Transplantation.
Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pulmonary hypertension (PH) associated with interstitial pneumonia (IP) has a poor prognosis, and lung transplantation (LT) is the only effective treatment option for severe cases. However, the waiting period for LT often exceeds the median survival time in these patients, and the effectiveness of pulmonary vasodilators during this period is not well established. In Case 1, a patient with scleroderma-related IP and PH was treated with sildenafil, which resulted in improved PH and successful single-lung transplantation. In Case 2, a patient with rheumatoid arthritis-related IP and PH was treated with tadalafil and macitentan, leading to successful single-lung transplantation. These cases suggest that pulmonary vasodilators may be valuable bridging therapies for patients with PH associated with IP who are awaiting LT.
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