Evidence map›Paper›PMID 40098950›Full record

ArticleFrontiers in immunology2025

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus.

Beatriz Moleirinho, Margarida Paulo-Pedro, Nicole C Martins, Emily Jelagat, Eller Conti, Tiago R Velho, Miguel Abecasis, Rui Anjos, Afonso R M Almeida, Ana E Sousa

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Beatriz Moleirinho *GIMM- Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Margarida Paulo-Pedro *GIMM- Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Nicole C Martins *GIMM- Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Emily JelagatGIMM- Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Eller ContiGIMM- Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Tiago R VelhoCardiothoracic Surgery Research Unit, Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Miguel AbecasisHospital de Santa Cruz, Unidade Local de Saúde de Lisboa Ocidental, Carnaxide, Portugal.
Rui AnjosHospital de Santa Cruz, Unidade Local de Saúde de Lisboa Ocidental, Carnaxide, Portugal.
Afonso R M AlmeidaGIMM- Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Ana E SousaGIMM- Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymus-committed regulatory T cells (Tregs) are essential for immune homeostasis. Recent findings stress their heterogeneity, suggesting possible alternate routes for thymic Treg development with unique features in humans, namely the clear evidence of Treg commitment at the double-positive (DP) stage and the presence of a significant population of CD8 single-positive (SP) FOXP3

Indexed as

Flow CytometryThymus GlandT-Lymphocytes, RegulatoryAdultAgedAged, 80 and overBiomarkersCell DifferentiationChildFemaleForkhead Transcription FactorsHumansImmunophenotypingMaleThymocytesBiomarkersForkhead Transcription FactorsFOXP3 protein, humanhuman immunologyregulatory T cellsspectral flow cytometryT cell developmentthymus

Identifiers

PMID40098950
PMCPMC11911493

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.