Evidence map›Paper›PMID 40098928›Full record

ArticleFrontiers in medicine2025

Regulation of DNA methylation in lesional tissue of children with atopic dermatitis.

Demet Kartal, Muhammed Hanefi Dirican, Serpil Taheri, Mehmet Memiş, Eda Öksüm Solak, Salih Levent Cinar, Murat Borlu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Demet KartalDermatology and Venereology Department, Erciyes University Medical School, Kayseri, Türkiye.
Muhammed Hanefi DiricanDermatology and Venereology Department, Tokat City Hospital, Tokat, Türkiye.
Serpil TaheriBetul Ziya Eren Genome and Stem Cell (GENKÖK) Center, Erciyes University, Kayseri, Türkiye.
Mehmet MemişBetul Ziya Eren Genome and Stem Cell (GENKÖK) Center, Erciyes University, Kayseri, Türkiye.
Eda Öksüm SolakDermatology and Venereology Department, Erciyes University Medical School, Kayseri, Türkiye.
Salih Levent CinarDermatology and Venereology Department, Erciyes University Medical School, Kayseri, Türkiye.
Murat BorluDermatology and Venereology Department, Erciyes University Medical School, Kayseri, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Genetic and epigenetic mechanisms have been shown to play a role in the pathogenesis of atopic dermatitis (AD). However, the role of genes involved in the establishment of DNA methylation has not yet been demonstrated. Methods: A total of 15 pediatric patients with AD and 15 healthy volunteers were included in this study. The mRNA gene expression levels of eight different genes involved in the regulation of DNA methylation were examined in the blood and tissue samples. Results: The mRNA expression levels of Conclusion: The results indicated that the DNA methylation pattern in the patients was hypermethylated, especially in the lesional tissue. The data obtained may contribute to the understanding of the epigenetic regulation of AD and aid in the development of new diagnostic and treatment options.

Indexed as

atopic dermatitisDNA methylationepigeneticpediatric atopic dermatitisTET1-2 and DNMT gene expression

Identifiers

PMID40098928
PMCPMC11913172

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