ArticleFrontiers in neurology2024
Cenobamate modulates EEG cortical activity and connectivity in individuals with drug-resistant epilepsy: a pharmaco-EEG study.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug-resistant focal epilepsy.Epilepsia open · 2026Article
- Quantitative electroencephalography as a next-generation tool in neurodiagnostics: significance, clinical applications, and practical interpretative frameworks.Frontiers in neuroscience · 2026Review
- Increase of Brivaracetam serum concentration with introduction of Cenobamate.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Quantitative electroencephalography (qEEG) metrics are demonstrated to correlate with and predict clinical response in individuals with epilepsy. Cenobamate is an effective anti-seizure medication recently approved as an add-on therapy for individuals with epilepsy, but its effects on qEEG are unknown. We aimed to evaluate the modulation of qEEG metrics induced by cenobamate and its relationship with clinical response. Methods: We performed a prospective study with a cohort of 18 individuals with epilepsy (8 women, 47 ± 16 years old) and 25 healthy subjects (HS). They underwent a 19-channel EEG before and 6 months after cenobamate administration. Power spectral density (PSD) and phase locking value (PLV) for delta, theta, alpha, beta, and gamma frequency bands were calculated. Correlation analysis and analysis of covariance exhibited significant cenobamate-induced changes in qEEG and their relationship with seizure frequency changes. A regression analysis was performed to evaluate the association with clinical responders. Results: A total of 11 out of 16 individuals with epilepsy (69%, with 2 dropping out) were cenobamate responders (≥50% seizure frequency reduction). Cenobamate did not modify any PSD parameter but induced significant changes in PLV levels ( Conclusion: Cenobamate induces an EEG connectivity modulation that is highly associated with cenobamate clinical response. Significance: Connectivity analysis of pharmaco-EEG can provide new hints toward the development of innovative biomarkers and precision medicine in individuals with epilepsy.
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