Evidence map›Paper›PMID 40098778›Full record

ArticleJournal of child & adolescent trauma2025

The Association between Childhood Adversity and the Conserved Transcriptional Response to Adversity (CTRA) in Sexual Minority Men.

Shareefa Dalvie, Michael J Li, Mariah M Kalmin, Steven W Cole, Dan J Stein, Steven J Shoptaw

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child & adolescent trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Childhood Adversities and the ATTACHInternational journal of environmental research and public health · 2024
    Trial
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Shareefa DalvieDivision of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-2333-4823
Michael J LiCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, USA.
Mariah M KalminCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, USA.
Steven W ColeDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA.
Dan J SteinSAMRC, Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Steven J ShoptawCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, USA.

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE) U01DA036267 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORBACH, PAMINA MAE, SHOPTAW, STEVEN J · 2013 to 2024
$20.5M
Optimizing PrEP Implementation and Cost-effectiveness among Sexual and Gender Minority Individuals with a Substance Use DisorderR01DA056888 · NIDA · FRIENDS RESEARCH INSTITUTE, INC. · PI MURPHY, SEAN M., REBACK, CATHY J · 2022 to 2025
$3.3M
Screen, Treat and Retain People with Primary Meth Use Disorder at MMT Clinics (STAR-OM+)R01DA050486 · NIDA · HANOI MEDICAL UNIVERSITY · PI LE, GIANG M, SHOPTAW, STEVEN J · 2020 to 2024
$2.3M
Trajectories of socially regulated gene expression, methamphetamine use, and viral load among HIV-positive men who have sex with men (MSM) receiving contingency managementK01DA051329 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, MICHAEL JONATHAN · 2021 to 2025
$947k
NIDA NIH HHS K01 DA051329NIDA NIH HHS R01 DA050486NIDA NIH HHS R01 DA056888NIDA NIH HHS U01 DA036267NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

Adverse childhood experiences (ACEs) increase risk for mental and physical health disorders in adulthood, particularly in individuals from sexual and ethnic minority groups. The effects of ACEs on health may be mediated by the immune system. The exact mechanisms by which an environmental exposure, such as childhood adversity, can affect the immune system are still unknown. The primary aim of this study was to determine whether early adversity is associated with significant changes in the expression of a predefined set of immune-related genes, known as the conserved transcriptional response to adversity (CTRA), in a diverse group (African American and Latino) of sexual minority men (SMM) ( Supplementary Information: The online version contains supplementary material available at 10.1007/s40653-024-00661-2.

Indexed as

Adverse childhood experiencesGene expressionHIVImmune systemSexual and gender minorities

Identifiers

PMID40098778
PMCPMC11910459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.