Evidence map›Paper›PMID 40098747›Full record

SynthesisFrontiers in human neuroscience2025

Transcutaneous and transcranial electrical stimulation for enhancing military performance: an update and systematic review.

Onno van der Groen, Sara A Rafique, Nick Willmot, Margaret G Murphy, Eulalia Tisnovsky, Tad T Brunyé

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Onno van der GroenDefence Science and Technology Group, Human and Decision Sciences, Department of Defence, Edinburgh, SA, Australia.
Sara A RafiqueDefence Science and Technology Laboratory, Salisbury, United Kingdom.
Nick WillmotDefence Science and Technology Group, Human and Decision Sciences, Department of Defence, Edinburgh, SA, Australia.
Margaret G MurphyU.S. Army DEVCOM Soldier Center, Natick, MA, United States.
Eulalia TisnovskyCenter for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, United States.
Tad T BrunyéU.S. Army DEVCOM Soldier Center, Natick, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Electrical stimulation (ES), including transcranial electrical stimulation (tES) and transcutaneous vagus nerve stimulation (tVNS), has shown potential for cognitive enhancement in military contexts. Various types of ES, such as transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), modulate neuronal membrane potentials and cortical excitability, potentially improving cognitive functions relevant to military training and operations. Methods: This systematic review updates previous findings by examining studies published between 2019 and 2024 that investigated electrical stimulation effects on cognitive performance in military personnel and tasks. We focused on whether the studies addressed key questions about the generalizability of lab findings to military tasks, the frequency and intensity of adverse effects, the impact of repeated ES administration, and the ethical and regulatory considerations for its use in potentially vulnerable military populations. Results: Eleven studies met the inclusion criteria; most demonstrated overall low to some concerns, however, two of these had overall high risk of bias. While tES and tVNS showed some promise for enhancing multitasking and visual search performance, the results were mixed, with no reliable effects on vigilance tasks. Discussion: The reviewed studies highlight the need for a better understanding of ES mechanisms, optimal stimulation parameters, and individual differences in response to ES. They also highlight the importance of conducting high-powered research in military settings to evaluate the efficacy, safety, and ethical implications of ES. Future research should address the generalizability of lab-based results to real-world military tasks, monitor the frequency and intensity of adverse effects, and explore the long-term impacts of repeated administration. Furthermore, ethical and regulatory considerations are crucial for the responsible application of ES in military contexts, and a series of outstanding questions is posed to guide continuing research in this domain.

Indexed as

human performancemilitaryperipheral nerve stimulationtranscranial alternating current stimulationtranscranial direct current stimulationtranscranial electrical stimulationvagus nerve stimulation

Identifiers

PMID40098747
PMCPMC11911350

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.