Evidence map›Paper›PMID 40098681›Full record

ArticleDiscover imaging2025

Deep learning imaging analysis to identify bacterial metabolic states associated with carcinogen production.

Maysam Orouskhani, Sarwesh Rauniyar, Norma Morella, Daniel Lachance, Samuel S Minot, Neelendu Dey

Abstract read
In one paragraph

Article in Discover imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maysam OrouskhaniTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA USA.
Sarwesh RauniyarTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA USA.
Norma MorellaTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA USA.
Daniel LachanceTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA USA.
Samuel S MinotMicrobiome Research Initiative, Fred Hutchinson Cancer Center, Seattle, WA USA.
Neelendu DeyTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA USA.

Funding

Understanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiomeU54CA274374 · NCI · FRED HUTCHINSON CANCER CENTER · PI Neelendu Dey · 2022 to 2026
$10.7M
NCI NIH HHS U54 CA274374
6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) is a globally prevalent cancer. Emerging research implicates the gut microbiome in CRC pathogenesis. Bacteria such as Methods: Light microscopy images of anaerobically cultured Results: For whole-image analysis, DIBaS-enhanced ResNet models achieved the best performance in distinguishing Conclusions: This study demonstrates feasibility of image-based deep learning models in identifying health-relevant gut bacterial metabolic states. Supplementary Information: The online version contains supplementary material available at 10.1007/s44352-025-00006-1.

Indexed as

Colorectal cancerDeep learningDeoxycholic acidMicrobiome

Identifiers

PMID40098681
PMCPMC11912549

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.