Evidence map›Paper›PMID 40098592›Full record

ArticleChemistry & biodiversity2025

South African Propolis: Anti-Helicobacter pylori Activity, Chemistry, and Toxicity.

Sarhana Dinat, Ané Orchard, Efficient Ncube, Weiyang Chen, Alvaro Viljoen, Sandy van Vuuren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarhana DinatDepartment of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-4040-6828
Ané OrchardDepartment of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-6767-7110
Efficient NcubeDepartment of Pharmaceutical Sciences, Faculty of Sciences, Tshwane University of Technology, Pretoria, South Africa.ORCID https://orcid.org/0000-0001-6278-3774
Weiyang ChenDepartment of Pharmaceutical Sciences, Faculty of Sciences, Tshwane University of Technology, Pretoria, South Africa.
Alvaro ViljoenDepartment of Pharmaceutical Sciences, Faculty of Sciences, Tshwane University of Technology, Pretoria, South Africa.ORCID https://orcid.org/0000-0002-6810-2981
Sandy van VuurenDepartment of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-4859-1845

Funding

Faculty of Research Committee Individual Research GrantNational Research FoundationNRF Thuthuka Fund 129672South African Medical Research Council
6 · The paper itself

Abstract

Propolis, a resin-like substance produced by bees, has previously shown antimicrobial activity against the ulcer-causing gut pathogen Helicobacter pylori. South African propolis, however, was yet to be investigated. This study aimed to investigate a comprehensive range of South African propolis for its antimicrobial activity against H. pylori and to investigate toxicity. A total of 51 samples were collected from around South Africa and comparatively analysed with three Brazilian samples. The antimicrobial broth microdilution assay was used to determine the minimum inhibitory concentration (MIC) of ethanolic propolis extracts against three clinical H. pylori strains. A total of 27 South African propolis extracts presented antimicrobial activity better than that of the Brazilian samples (MIC ≤ 0.51 mg/mL). Samples with the best anti-H. pylori activity were selected for chemical analysis using ultra-performance liquid chromatography-mass spectrometry. The compounds pinocembrin, 3-O-acetylpinobanksin, and pinobanksin were found to be the most abundant. All propolis extracts investigated in this study were considered non-toxic (mortality < 50%) when investigated using the brine shrimp lethality assay. This study demonstrates the in vitro potential of utilizing propolis for treating H. pylori infections and highlights the possible compounds responsible for the activity observed.

Indexed as

Anti-Bacterial AgentsHelicobacter pyloriPropolisAnimalsArtemiaDose-Response Relationship, DrugMicrobial Sensitivity TestsSouth AfricaStructure-Activity RelationshipAnti-Bacterial AgentsPropolisbiological activityHelicobacter pyloriliquid chromatographypropolistoxicity

Identifiers

PMID40098592
PMCPMC12351434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.